Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Retrospective

Outcome Measure:

Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

Outcome Description:

A GWAS reported a novel association between the TP63 locus and risk of lung adenocarcinoma; however, this association did not achieve genome-wide significance among never-smoking males or females. We genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 500 never-smoking female lung cancer cases and 500 never-smoking female controls from China. Genetic variation in rs10937405 was associated with lung adenocarcinoma. Our findings provide strong evidence that genetic variation in TP63 is associated with risk of lung adenocarcinoma among non-smoking females.

Outcome Time Frame:

2011-12

Safety Issue:

Yes

Principal Investigator

Chen Kexin, M.D., Ph.D

Investigator Role:

Study Director

Investigator Affiliation:

Tianjin Medical University Cancer Institute and Hospital

Authority:

China: Ethics Committee

Study ID:

TMU-CIH-GWASLC-Epi-Tianjin

NCT ID:

NCT01255059

Start Date:

June 2010

Completion Date:

December 2014

Related Keywords:

• Non-Small Cell Lung Cancer
• Primary Carcinoma
• Genome-wide association studies(GWAS)
• Single nucleotide polymorphism(SNP)
• Lung cancer
• Carcinoma
• Carcinoma, Non-Small-Cell Lung
• Lung Neoplasms