Know Cancer

or
forgot password

Tumor Angiogenesis in Non-Small Cell Lung (NSCLC), Colorectal, Breast, Esophageal, Head and Neck Cancer: Radiology-Pathology and Prognostic Correlation


N/A
N/A
N/A
Open (Enrolling)
Both
Breast Cancer, Colorectal Cancer, Esophageal Cancer, Head and Neck Cancer, Lung Cancer

Thank you

Trial Information

Tumor Angiogenesis in Non-Small Cell Lung (NSCLC), Colorectal, Breast, Esophageal, Head and Neck Cancer: Radiology-Pathology and Prognostic Correlation


OBJECTIVES:

- To determine the ability of preoperative fludeoxyglucose F 18 positron emission
tomography/computed tomography (PET/CT) scanning in assessing tumor angiogenesis in
patients with potentially operable non-small cell lung cancer, colorectal cancer,
breast cancer, esophageal cancer, or head and neck cancer.

- To determine the ability of preoperative fludeoxyglucose F 18 PET/CT scanning in
assessing prognosis by means of measuring angiogenesis in these patients.

OUTLINE: All patients undergo fludeoxyglucose F 18 positron emission tomography/computed
tomography (PET/CT) scanning for staging, tumor perfusion measurement/angiogenesis, and
glucose metabolism. If staging confirms operable disease, then the patient proceeds to
surgery as planned. Resected tumor tissue samples are examined for tumor angiogenesis in the
various cancer types.

Some patients undergo a half-dose of rubidium Rb-82 or 18F-fluoromisonidazole or [18F]-ML-10
PET scan or fluorescence angiography. Patients with colorectal cancer undergo a CT scan for
perfusion of the tumor after the staging PET/CT. Patients with breast cancer undergo
infrared thermometry as well as a MRI scan for staging and to predict angiogenesis.

After completion of study therapy, patients are followed up at 1 month and then every 6
months for 5 years.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of non-small cell lung cancer, colorectal cancer, breast cancer, esophageal
cancer, or head and neck cancer

- Potentially operable disease

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Not specified

- Menopausal status not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Interventional

Study Design:

Primary Purpose: Diagnostic

Outcome Measure:

Clinical, radiological, and pathological correlation

Safety Issue:

No

Principal Investigator

Peter Ell, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University College London Hospitals

Authority:

Unspecified

Study ID:

CDR0000689973

NCT ID:

NCT01254591

Start Date:

November 2006

Completion Date:

Related Keywords:

  • Breast Cancer
  • Colorectal Cancer
  • Esophageal Cancer
  • Head and Neck Cancer
  • Lung Cancer
  • stage IA non-small cell lung cancer
  • stage IB non-small cell lung cancer
  • stage IIA non-small cell lung cancer
  • stage IIB non-small cell lung cancer
  • stage IIIA non-small cell lung cancer
  • stage I colon cancer
  • stage IIA colon cancer
  • stage IIB colon cancer
  • stage IIC colon cancer
  • stage IIIA colon cancer
  • stage I rectal cancer
  • stage IIA rectal cancer
  • stage IIB rectal cancer
  • stage IIC rectal cancer
  • stage IIIA rectal cancer
  • stage IA breast cancer
  • stage IB breast cancer
  • stage II breast cancer
  • stage IIIA breast cancer
  • stage IIIB breast cancer
  • stage I esophageal cancer
  • stage II esophageal cancer
  • stage III esophageal cancer
  • stage I hypopharyngeal cancer
  • stage II hypopharyngeal cancer
  • stage III hypopharyngeal cancer
  • stage I laryngeal cancer
  • stage II laryngeal cancer
  • stage III laryngeal cancer
  • stage I lip and oral cavity cancer
  • stage II lip and oral cavity cancer
  • stage III lip and oral cavity cancer
  • stage I nasopharyngeal cancer
  • stage II nasopharyngeal cancer
  • stage III nasopharyngeal cancer
  • stage I oropharyngeal cancer
  • stage II oropharyngeal cancer
  • stage III oropharyngeal cancer
  • stage I paranasal sinus and nasal cavity cancer
  • stage II paranasal sinus and nasal cavity cancer
  • stage III paranasal sinus and nasal cavity cancer
  • stage I salivary gland cancer
  • stage II salivary gland cancer
  • stage III salivary gland cancer
  • tongue cancer
  • Breast Neoplasms
  • Carcinoma, Non-Small-Cell Lung
  • Colorectal Neoplasms
  • Esophageal Diseases
  • Esophageal Neoplasms
  • Head and Neck Neoplasms
  • Lung Neoplasms

Name

Location