Inclusion Criteria:

- Histopathologically proven malignant melanoma.

- Presence of measurable and injectable soft tissue metastases either in clinical stage
III or stage IV M1a.

- Males or females, age >/= 18 years.

- Either without, or after one line of prior systemic treatment for metastatic disease.

- ECOG performance status < 2.

- LDH < 2 x the upper limit of normal.

- Life expectancy of at least 12 weeks.

- Absolute neutrophil count > 1.5 x 10^9/L.

- Hemoglobin > 9.0 g/dL.

- Platelets > 100 x 10^9/L.

- Total bilirubin ≤ 30 µmol/L (or ≤ 2.0 mg/dl).

- ALT and AST ≤ 2.5 x the upper limit of normal (ULN) (5.0 x ULN for patients with
hepatic involvement with tumor).

- Serum creatinine < 1.5 x ULN.

- All acute toxic effects (excluding alopecia) of any prior therapy must have resolved
to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events
(CTCAE) (v4.02) Grade ≤ 1 unless otherwise specified above.

- Negative serum pregnancy test (for women of child-bearing potential only) at
screening.

- If of childbearing potential, agreement to use adequate contraceptive methods (e.g.,
oral contraceptives, condoms, or other adequate barrier controls, intrauterine
contraceptive devices, or sterilization) beginning at the screening visit and
continuing until 3 months following last treatment with study drug.

- Able to provide written Informed Consent.

- Willingness and ability to comply with the scheduled visits, treatment plan,
laboratory tests and other study procedures.

Exclusion Criteria:

- Primary ocular melanoma.

- Presence of visceral metastases at screening.

- Evidence of active brain metastases at screening.

- Previous or concurrent cancer that is distinct in primary site or histology from the
cancer being evaluated in this study except cervical carcinoma in situ, treated basal
cell carcinoma, superficial bladder tumors (TA, Tis & Ti) or any cancer curatively
treated < 5 years prior to study entry.

- History of HIV infection or infectious hepatitis B or C.

- Presence of active infections (e.g. requiring antimicrobial therapy) or other severe
concurrent disease, which, in the opinion of the investigator, would place the
patient at undue risk or interfere with the study.

- History within the last year of acute or subacute coronary syndromes including
myocardial infarction, unstable or severe stable angina pectoris.

- Inadequately controlled cardiac arrhythmias including atrial fibrillation.

- Heart insufficiency (> Grade II, New York Heart Association (NYHA) criteria).

- Uncontrolled hypertension.

- Ischemic peripheral vascular disease (Grade IIb-IV).

- Severe diabetic retinopathy.

- Active autoimmune disease.

- History of organ allograft or stem cell transplantation.

- Recovery from major trauma including surgery within 4 weeks prior to administration
of study treatment.

- Known history of allergy to IL2, or other intravenously administered human
proteins/peptides/antibodies.

- Breast feeding female.

- Anti-tumor therapy within 4 weeks of the administration of study treatment (except
small surgery).

- Previous in vivo exposure to monoclonal antibodies for biological therapy in the 6
weeks before administration of study treatment.

- Planned administration of growth factors or immunomodulatory agents within 7 days
before the administration of study treatment.

- Patients in need of systemic treatment for rapidly progressive systemic disease
during study treatment and up to 2 weeks after injection of L19IL2.

- Patient requires, or is taking, corticosteroids or other immunosuppressant drugs on a
long-term basis. Limited use of corticosteroids to treat or prevent acute
hypersensitivity reactions is not considered an exclusion criterion.

- Any condition, that in the opinion of the investigator could hamper compliance with
the study protocol.