Inclusion Criteria

- INCLUSION CRITERIA:

Patients must have histologically confirmed (by the Laboratory of Pathology, NCI) solid
tumors that are metastatic or unresectable and for which standard therapies do not exist
or are no longer effective.

There are no restrictions on prior therapy.

Age greater than or equal to18 years. Because no dosing or adverse event data are
currently available on the use of EZN-2208 in combination with bevacizumab in patients
less than 18 years of age, children are excluded from this study, but will be eligible for
future pediatric Phase I combination trials.

ECOG performance status less than or equal to 2 (Karnofsky greater than or equal to 60%

Life expectancy of greater than 3 months.

Patients must have normal organ and marrow function as defined below:

leukocytes greater than or equal to 3,000/mcL

absolute neutrophil count greater than or equal to 1,500/mcL

platelets greater than or equal to 100,000/mcL

total bilirubin less than or equal to 1.5 times the institutional upper limit of normal

AST(SGOT)/ALT(SGPT) less than or equal to 2.5 times the institutional upper limit of
normal

creatinine less than or equal to 1.5 times the institutional upper limit of normal

OR

creatinine clearance greater than or equal to 60 mL/min/1.73 m(2) for patients with
creatinine levels above institutional normal.

The effects of EZN-2208 on the developing human fetus are unknown. For this reason and
because bevacizumab is known to be teratogenic, women of childbearing potential and men
must agree to use adequate contraception (hormonal or barrier method of birth control;
abstinence) prior to study entry, for the duration of study participation, and for 3
months after completion of study. Should a woman become pregnant or suspect she is
pregnant while participating in this study, she should inform her treating physician
immediately.

Ability to understand and the willingness to sign a written informed consent document.

Disease amenable to biopsy, and willingness to undergo biopsies.

EXCLUSION CRITERIA:

Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for
nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered
from adverse events due to agents administered more than 4 weeks earlier. Patients must be
>= 2 weeks since receiving study drug as a participant in a Phase 0 study (also referred
to as an early Phase I study where a subtherapeutic dose of drug is administered).

Patients may not be receiving any other investigational agents.

Patients with a diagnosis of colorectal cancer, who have previously failed treatment with
a topoisomerase I inhibitor. Patients with all other types of malignancies will be
considered for eligibility regardless of prior exposure to topoisomerase 1 inhibitors.

History of allergic reactions attributed to compounds of similar chemical or biologic
composition to EZN-2208 or bevacizumab.

Uncontrolled intercurrent illness including, but not limited to, clinically significant
cardiovascular disease as defined below, or psychiatric illness/social situations that
would limit compliance with study requirements.

Pregnant women are excluded from this study because bevacizumab is an antiangiogenic agent
with the potential for teratogenic or abortifacient effects. Because there is an unknown
but potential risk for adverse events in nursing infants secondary to treatment of the
mother with EZN-2208, breastfeeding should be discontinued if the mother is treated with
EZN-2208.

HIV-positive patients on combination antiretroviral therapy are ineligible because of the
potential for pharmacokinetic interactions with EZN-2208. In addition, these patients are
at increased risk of lethal infections when treated with marrowsuppressive therapy.
Appropriate studies will be undertaken in patients receiving combination antiretroviral
therapy when indicated.

Urine protein should be screened by urine analysis. If protein is 2+ or higher, 24-hour
urine protein should be obtained and the level should be < 1000 mg for patient enrollment.

Serious or non-healing wound, ulcer, or bone fracture. History of abdominal fistula,
gastrointestinal perforation, or intra-abdominal abscess within the past 6 months.

Invasive procedures defined as follows:

- Major surgical procedure, open biopsy, or significant traumatic injury within the
past 28 days.

- Anticipation of need for major surgical procedures during the course of the study.

Significant vascular disease (e.g., aortic aneurysm, requiring surgical repair or recent
peripheral arterial thrombosis) within the past 6 months.

Known CNS disease except for treated brain metastasis. Treated brain metastases are
defined as having no ongoing requirement for steroids and no evidence of progression or
hemorrhage after treatment for at least 3 months, as ascertained by clinical examination
and brain imaging (MRI or CT). Patients receiving EIAED anticonvulsants will not be
eligible to participate (Appendix B). Patients on non-EIAED may be enrolled at the
discretion of the PI. Treatment for brain metastases may include whole brain radiotherapy
(WBRT), radiosurgery (RS; Gamma Knife, LINAC, or equivalent), or a combination as deemed
appropriate by the treating physician.

Patients with clinically significant cardiovascular disease are excluded:

- Inadequately controlled hypertension (systolic blood pressure > 160 mm Hg and/or
diastolic blood pressure > 90 mm Hg despite antihypertensive medication)

- History of stroke/cerebrovascular accident within 6 months

- Myocardial infarction or unstable angina within 6 months

- New York Heart Association grade II or greater congestive heart failure

- Serious and inadequately controlled cardiac arrhythmia

- Significant vascular disease (e.g., aortic aneurysm, history of aortic dissection)

- Clinically significant peripheral vascular disease

Evidence of bleeding diathesis or coagulopathy. Patients on therapeutic anticoagulation
will be excluded.

Patients with known hypersensitivity to Chinese hamster ovary cell products or other
recombinant human antibodies.