Oral Curcumin for Radiation Dermatitis in Breast Cancer Patients
Radiation is a toxic agent and a widely accepted form of treatment for various types of
cancer. Approximately half of all women with breast cancer receive radiation therapy.
Despite advances in medical technology, radiation therapy still causes severe skin effects.
Radiation dermatitis occurs in approximately 90% of patients and ranges in severity from
mild redness to more severe skin changes. Dermatitis is a common side effect of radiation
treatment, but few effective treatments have been developed for it; currently, there is no
standard treatment for the prevention of radiation-induced dermatitis. Curcumin is a
natural compound found in both turmeric and curry powder. It has been used for centuries as
a spice (curry), a food coloring and as a food preservative. Curcumin is non-toxic and has
been found to enhance the functions of normal tissues.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Prevention
To evaluate the degree to which curcumin can reduce radiation-induced skin reactions in breast cancer patients receiving radiotherapy.
The outcome measures will be the severity of radiation dermatitis, using the RDS scale, at the end of treatment in each treatment arm. (Objective: To examine the efficacy of curcumin in preventing and/or reducing the severity of dermatitis in radiation treatment site in breast cancer patients).
Julie Ryan, PhD, MPH
University of Rochester
United States: Food and Drug Administration