Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer
Every surgical intervention represents a stress for patient's organism. During the
operation, numerous changes in the patient's metabolism take place, that are termed surgical
stress response. Leading cause of surgical stress response is tissue destruction that always
accompanies operations. Surgical stress response is effected through activation of
hypothalamus-pituitary-adrenal axis and through sympathetic activation.
The consequences of surgical stress response are numerous. Surgical stress response is
essential to uneventful postoperative recovery. On the other hand, excessive surgical stress
response may lead to serious postoperative complications, such as heart and kidney failure,
venous thrombosis, disruption of operative wound and wound infection.
In prior studies the investigators have shown the kinetics of postoperative serum
interleukin changes after radical resection of gastric cancer.
This study aims at determining reliable markers of surgical stress response severity in
patients undergoing radical resection of colorectal cancer.
Observational Model: Case-Only, Time Perspective: Prospective
Postoperative changes of serum cytokine levels
Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values.
1 day, 2 days and 7 days postoperatively
Drazen Servis, M.D., Ph.D.
University Hospital Dubrava
Croatia: Ethics Committee