Know Cancer

forgot password

Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer

20 Years
90 Years
Open (Enrolling)
Colorectal Cancer

Thank you

Trial Information

Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer

Every surgical intervention represents a stress for patient's organism. During the
operation, numerous changes in the patient's metabolism take place, that are termed surgical
stress response. Leading cause of surgical stress response is tissue destruction that always
accompanies operations. Surgical stress response is effected through activation of
hypothalamus-pituitary-adrenal axis and through sympathetic activation.

The consequences of surgical stress response are numerous. Surgical stress response is
essential to uneventful postoperative recovery. On the other hand, excessive surgical stress
response may lead to serious postoperative complications, such as heart and kidney failure,
venous thrombosis, disruption of operative wound and wound infection.

In prior studies the investigators have shown the kinetics of postoperative serum
interleukin changes after radical resection of gastric cancer.

This study aims at determining reliable markers of surgical stress response severity in
patients undergoing radical resection of colorectal cancer.

Inclusion Criteria:

- Pathohistologically verified colorectal cancer or adenoma with dysplasia

Exclusion Criteria:

- Distant metastases noticed before or during surgery

- History of autoimmune diseases or immunodeficiencies

- Use of immunomodulatory drugs within 1 year prior to surgery

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Postoperative changes of serum cytokine levels

Outcome Description:

Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values.

Outcome Time Frame:

1 day, 2 days and 7 days postoperatively

Safety Issue:


Principal Investigator

Drazen Servis, M.D., Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Hospital Dubrava


Croatia: Ethics Committee

Study ID:




Start Date:

August 2010

Completion Date:

December 2011

Related Keywords:

  • Colorectal Cancer
  • Colorectal cancer
  • Surgical stress response
  • interleukins
  • Colorectal Neoplasms