Intermittent Versus Continuous Erlotinib With Concomitant Modified 'Xelox' (q3W) in First-line Treatment of Metastatic Colorectal Cancer
- Age ≥ 18 years.
- ECOG performance status of 0-2.
- Histological proof of adenocarcinoma of colon or rectum with evidence of metastatic
- At least one unidimensionally measurable lesion with a diameter >20 mm using
conventional CT or MRI scans, or > 10 mm with spiral CT
- No prior drug treatment or chemotherapy for metastatic disease.
- No prior HER2 or EGFR inhibitors. No prior Oxaliplatin in any clinical setting.
- Absolute granulocyte count > 1.5 x 109/L, platelet count > 100 x 109/L, hemoglobin
level > 9.0 g/L, INR < 1.5.
- Adequate renal & hepatic functions: serum creatinine < 1.5 x upper limit of normal
(ULN) or calculated creatinine clearance > 50ml/min, serum bilirubin < 1.5 x ULN, ALT
< 2.5 x ULN or < 5 x ULN in case of liver metastases, albumin level > 30g/dL).
- Prior adjuvant or neoadjuvant chemotherapy for non-metastatic CRC is allowed if > 3
months has elapsed since the last dose of chemotherapy.
- Prior open surgery is allowed if > 28 days* has elapsed since the date of surgery,
wound healing is satisfactory and recovery from any complications from the surgery is
adequate. (*For laparoscopic surgery, > 14 days from the date of surgery).
- No serious medical conditions such as myocardial infarction within 6 months prior to
entry, or any other medical conditions that might be aggravated by treatment
- Prior history of any malignancies, except basal cell cancer of skin, cervical CIN.
- Treatment with radiotherapy < 30 days.
- Pregnant or lactating females
- Sexually active males and females (of childbearing potential) unwilling to practice
contraception during the study.
- Patients who have not recovered from surgery or other medical illness such as
- Evidence of central nervous system disease. Patients with a history of uncontrolled
seizures, central nervous disorders or psychiatric disability judged by the
investigator to be clinically significant precluding informed consent or interfering
with compliance for oral drug intake should be excluded from the study
- Patients lacking physical integrity of upper gastrointestinal tract or malabsorption
syndrome or unable to swallow tablets.
- Prior unanticipated severe reaction to fluoropyrimidine therapy (with or without
documented DPD deficiency).
- Interstitial pneumonia or extensive symptomatic fibrosis of the lungs.
- Requirement for concurrent use of the antiviral agent sorivudine (antiviral) or
chemically related analogues, such as brivudine.
- Known peripheral neuropathy ≥ NCI CTC grade 1.
- Current or recent (within 10 days prior to study treatment start) use of full-dose
oral anticoagulant (e.g. warfarin) or thrombolytic agent.