Inclusion Criteria:

- Histologic proof of breast cancer (invasive ductal or lobular carcinoma). Breast
sarcoma and lymphoma are not eligible.

- Clinical diagnosis of locally advanced breast cancer (Stage IIB (T3,N0,M0), Stage
IIIA, IIIB, or IIIC, according to American Joint Committee on Cancer (AJCC)
Tumour-Node-Metastasis (TNM) Cancer Staging), including inflammatory breast cancer.

- Ability to undergo neoadjuvant chemotherapy.

Exclusion Criteria:

- Evidence of metastatic disease (identified on chest x-ray, liver ultrasound, bone
scan or other imaging tests);

- Previous chemotherapy or hormonal therapy for breast cancer;

- Significant concurrent medical problems that result in the patient being unfit for
surgery (e.g. uncontrolled diabetes, active cardiac disease, severe chronic
obstructive pulmonary disease);

- Known pregnancy or lactating female (e.g. positive serum beta human chorionic
gonadotropin (B-hCG) pregnancy test);

- Inability to lie supine for imaging with Positron Emission Tomography (PET);

- Any contraindication to undergoing Magnetic Resonance Imaging (MRI) or PET;

- Currently receiving Antabuse;

- Inability to provide informed consent (e.g. dementia or severe cognitive impairment).