A Phase II Study of the Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients Undergoing Chemotherapy
To conduct a feasibility pilot to assess preliminary efficacy of a 6 week course of
ibuprofen (200 mg BID with does 8 hours apart) and a structured home based
walking/progressive resistance program, EXCAP, alone or together, on cognitive function and
levels of inflammatory molecules among cancer patients receiving chemotherapy (beginning at
cycle 2). If these interventions prove to be useful and have potential benefit, they could
have a substantial impact on treating cognitive difficulties experienced by cancer patients
as well as improve quality of life. Moreover, if there is an effect of these interventions
on cognitive functioning and inflammation, we will gain more knowledge of a possible
mechanism of chemotherapy-related cognitive difficulties.
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Effects of Physical Activity and Ibuprofen on Cognitive Function in Cancer Patients Undergoing Chemotherapy
Exercise and Ibuprofen (combined or alone) will lead to higher memory performances as assessed by the objective CANTAB delayed matching to sample task in cancer patients receiving adjuvant chemotherapy.
Michelle C Janelsins, Ph.D.
University of Rochester
United States: Institutional Review Board
|University of Rochester||Rochester, New York 14642|