Allogenic Transplantation of Ex-vivo Expanded CB Progenitors for Haematological Disorders
Stem cell transplantation is a curative approach for patients with hematological
malignancies. Umbilical cord blood is a source of stem cells for transplantation in patients
with no related donor. However, in adults, the number of stem cells in a single unit, may be
too low to allow engraftment, and the time to engraftment may be prolonged, increasing the
risks of the transplant. In this study, we expand part of the cord blood unit, in the lab,
trying to increase unit size, such that it would be suitable for adults, and would allow
safe engraftment.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Safety
Number of patients with adverse events during infusion
1 month
Yes
Arnon Nagler, MD
Principal Investigator
Chaim Sheba Medical Center
Israel: Israeli Health Ministry Pharmaceutical Administration
SHEBA-10-7959-AN-CTIL
NCT01235468
June 2012
November 2015
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