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Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI) in Non-Cirrhotic Patients - A Double Blind International Multicenter Study


N/A
18 Years
90 Years
Not Enrolling
Both
Neoplasms

Thank you

Trial Information

Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI) in Non-Cirrhotic Patients - A Double Blind International Multicenter Study


Magnetic Resonance Imaging (MRI) is currently the method of choice for non-invasive
diagnosis of primary liver tumors. However, differentiation of hepatocellular carcinoma
(HCC) from adenoma and focal nodular hyperplasia (FNH) remains challenging, particularly in
non-cirrhotic patients.


Inclusion Criteria:



- Histopathological diagnosis of Hepatocellular Cancer (HCC), Adenoma and/or Focular
nodular hyperplasia (FNH).

- Patients that received a pre-operative Magnetic Resonance Imaging (MRI).

- Patients that underwent liver resection with an intention to cure.

- Patient over 18 years of age

Exclusion Criteria:

- Other histopathological diagnosis such as cysts and hemangiomas.

- Patient age less than 18 years of age.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

Inter-observer agreement among expert radiologists in diagnosing primary liver tumors by Magnetic Resonance Imaging (MRI).

Outcome Description:

Inter-observer agreement for categorical data will by assessed by the Fliess' kappa (good agreement >0.7).

Outcome Time Frame:

December 2010

Safety Issue:

No

Principal Investigator

Stefan Breitenstein, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Hospital Zurich, Department of Visceral and Transplant Surgery, Zurich, Switzerland

Authority:

Switzerland: Swissmedic

Study ID:

MRI_Liver_Tumours_Evlauation

NCT ID:

NCT01234701

Start Date:

October 2010

Completion Date:

May 2012

Related Keywords:

  • Neoplasms
  • Liver
  • Neoplasms
  • Magnetic Resonance Imaging
  • Surgery
  • Pathology
  • Neoplasms
  • Liver Neoplasms

Name

Location

Harvard Medical School, Massachusetts General Hospital, and Beth Israel Deaconess Medical CenterBoston, Massachusetts  02117-0825
St. Louis University, Liver CenterSaint Louis, Missouri  63110-0250