Immunologic Profile of Patients With Newly Diagnosed Medulloblastoma at Initial Diagnosis and During Standard Radiation and Chemotherapy
- Evaluate the fraction of peripherally circulating T-regulatory cells (T_regs) in
pediatric patients with newly diagnosed medulloblastoma and compare it to the levels
found in a control group of patients undergoing craniectomy for Chiari malformation.
- Evaluate the longitudinal effects of standard radiotherapy and chemotherapy regimens on
the overall population of lymphocytes as well as the fraction of T_reg cells in
patients with medulloblastoma.
- Determine the baseline fraction of T_reg cells in those with non-medulloblastoma
posterior fossa tumors compared to levels found in patients undergoing decompression
for Chiari malformation.
OUTLINE: This is a multicenter study.
Patients with Chiari malformation and patients with posterior fossa tumor undergo standard
surgery. Patients with posterior fossa tumor also receive standard radiotherapy and
Blood samples are collected at baseline and periodically to measure the level of circulating
Masking: Open Label, Primary Purpose: Basic Science
Peripherally circulating T-regulatory (T-reg) cells in patients with medulloblastoma or Chiari malformation
Sri Gururangan, MD
Duke Cancer Institute
United States: Food and Drug Administration
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|
|Children's National Medical Center||Washington, District of Columbia 20010-2970|
|Children's Memorial Hospital - Chicago||Chicago, Illinois 60614|
|St. Jude Children's Research Hospital||Memphis, Tennessee 38105-2794|
|Cincinnati Children's Hospital Medical Center||Cincinnati, Ohio 45229-3039|
|Childrens Hospital Los Angeles||Los Angeles, California 90027|
|Lucile Packard Children's Hospital at Stanford University Medical Center||Palo Alto, California 95798|
|Children's Hospital of Pittsburgh of UPMC||Pittsburgh, Pennsylvania 15213|
|Duke Cancer Institute||Durham, North Carolina 27710|
|Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital||Houston, Texas 77030-2399|
|NCI - Pediatric Oncology Branch||Bethesda, Maryland|