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Regulation of S100A10 by the PML-RAR-alpha Oncoprotein


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Not Enrolling
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Leukemia

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Trial Information

Regulation of S100A10 by the PML-RAR-alpha Oncoprotein


OBJECTIVES:

- Demonstrate that S100A10 is expressed on APL cells and that levels of S100A10
correspond to the amount of fibrinolytic activity.

- Evaluate the impact of ATRA on S100A10 level and fibrinolytic activity in vitro.

- Evaluate the impact of S100A10 knockdown on fibrinolytic activity.

- Correlate in vitro findings in cell culture to primary patient samples both pre- and
post-ATRA therapy.

OUTLINE: This is a multicenter study.

Previously collected samples are analyzed via flow cytometry and western blot analysis. Cell
surface levels of S100A10 and annexin A2 are correlated to the promyelocyte population and
total protein levels are examined to determine total annexin A2 and S100A10 in acute
promyelocytic leukemia cells.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of acute promyelocytic leukemia

- Available cryopreserved cells from diagnosis or cryopreserved cells from remission
(germline)

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Demonstration that S100A10 is expressed on acute promyelocytic leukemia cells and that levels of S100A10 correspond to the amount of fibrinolytic activity

Safety Issue:

No

Principal Investigator

Jason N. Berman, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

IWK Health Centre

Authority:

United States: Federal Government

Study ID:

CDR0000687909

NCT ID:

NCT01232855

Start Date:

November 2010

Completion Date:

Related Keywords:

  • Leukemia
  • adult acute myeloid leukemia with t(15;17)(q22;q12)
  • adult acute promyelocytic leukemia (M3)
  • childhood acute promyelocytic leukemia (M3)
  • adult acute myeloid leukemia in remission
  • untreated adult acute myeloid leukemia
  • childhood acute myeloid leukemia in remission
  • untreated childhood acute myeloid leukemia and other myeloid malignancies
  • Leukemia
  • Leukemia, Promyelocytic, Acute

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