Does Androgen Suppression Treatment In Prostate Cancer Reduce Myocardial Blood Flow Reserve?
Treatment group: Prior to the initiation of AST, subjects will have a baseline N-13-ammonia
PET scan and a brachial artery ultrasound at the University of Ottawa Heart Institute. Blood
glucose and a lipid profile will be obtained. These tests will be repeated 6 - 9 months
after starting AST.
Cancer control group: The same testing and intervals will be performed. Normals control
group: Baseline testing will be done to establish a normal.
Intervention Model: Single Group Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Screening
myocardial flow reserve
The change in global absolute MFR between baseline and follow up PET studies, at a patient level. MFR is defined as the ratio between regional blood flow with maximum vasodilation and baseline regional blood flow.
6 - 9 months
Terrence Ruddy, MD
University of Ottawa Heart Institute
Canada: Health Canada
HI Protocol #2008341-01H