Perspective Evaluation of Hormones Involved in Serum Phosphate Homeostasis in Patients With Metastatic Renal Cells Carcinoma or Hepatocellular Carcinoma Treated With Sorafenib. Multicenter Cohort Study
Several tyrosin kinase inhibitors are able to induce hypophosphatemia but the mechanisms
underling this metabolic disorder are unknown.
Sorafenib is probably the drug in which this metabolic disturbance is most frequent. The aim
of the study is identify variation of blood serum analites involved in hypophosphatemia in
patients with advanced renal cells carcinoma and hepatocarcinoma in treatment with
sorafenib.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Identify the value variations of hormones involved in phosphate homeostasis during sorafenib administration
Assess the effects of sorafenib hormones involved in phosphate homeostasis
one year
No
Italy: The Italian Medicines Agency
662010
NCT01230697
June 2010
September 2011
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