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Promoter Methylation in MLL-Rearranged Childhood AML


N/A
1 Year
18 Years
Open (Enrolling)
Both
Leukemia

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Trial Information

Promoter Methylation in MLL-Rearranged Childhood AML


OBJECTIVES:

- To determine whether the pattern of global and TSG-specific promoter CpG island
hypermethylation and gene silencing that we have shown characterizes MLL-rearranged
(MLL-r) infant bilineage ALL is also characteristic of other subsets of MLL-r leukemia.

OUTLINE: Previously collected cryopreserved cells from diagnosis are analyzed for promoter
methylation via HELP arrays, gene expression arrays, and RT-qPCR.

PROJECTED ACCRUAL: A total of 32 samples (8 from each of 4 biologically defined cohorts)
will be analyzed.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Available cryopreserved cells from diagnosis

- At least 2 x 10^7 viably cryopreserved cells

- One of the following biologically defined cytogenetics/molecular cohorts:

- t(9;11)

- t(11;19)

- Other 11q23 translocations

- Normal cytogenetics

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Identification of differential patterns of promoter hypermethylation and gene expression in pairwise comparisons with other cohorts and normal controls

Safety Issue:

No

Principal Investigator

Patrick N. Brown, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

CHRISTUS Santa Rosa Cancer Center at CHRISTUS Santa Rosa Hospital - City Centre

Authority:

United States: Federal Government

Study ID:

CDR0000687646

NCT ID:

NCT01229956

Start Date:

November 2010

Completion Date:

Related Keywords:

  • Leukemia
  • childhood acute myeloid leukemia in remission
  • recurrent childhood acute myeloid leukemia
  • untreated childhood acute myeloid leukemia and other myeloid malignancies
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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