Promoter Methylation in MLL-Rearranged Childhood AML
- To determine whether the pattern of global and TSG-specific promoter CpG island
hypermethylation and gene silencing that we have shown characterizes MLL-rearranged
(MLL-r) infant bilineage ALL is also characteristic of other subsets of MLL-r leukemia.
OUTLINE: Previously collected cryopreserved cells from diagnosis are analyzed for promoter
methylation via HELP arrays, gene expression arrays, and RT-qPCR.
PROJECTED ACCRUAL: A total of 32 samples (8 from each of 4 biologically defined cohorts)
will be analyzed.
Identification of differential patterns of promoter hypermethylation and gene expression in pairwise comparisons with other cohorts and normal controls
Patrick N. Brown, MD
CHRISTUS Santa Rosa Cancer Center at CHRISTUS Santa Rosa Hospital - City Centre
United States: Federal Government