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Magnetic Resonance Elastography (MRE) of Uterine Fibroids

18 Years
65 Years
Open (Enrolling)
Uterine Fibroids

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Trial Information

Magnetic Resonance Elastography (MRE) of Uterine Fibroids

This is a single-site, non-randomized pilot study to determine whether Magnetic Resonance
Elastography (MRE) can be optimized for clinical use as part of the patients routine
clinical imaging and to correlate with MR signal characteristics of the uterine fibroid.

MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging


Specific Aim 1: To acquire magnetic resonance elastography images on women who have a
clinically ordered pelvic magnetic resonance imaging (MRI) for uterine fibroids.

Specific Aim 2: To examine the correlation between MRE stiffness values and MR T2 signal
characteristics for uterine fibroids. For a subset of patients going on to surgery
correlation with pathology can also be performed.

This study will seek to determine whether MRE can be performed in the pelvis on a routine
clinical basis as well as correlating the MRE findings with magnetic resonance signal
characteristics. There are no additional risks to the patient and no additional cost to the
MRI exam.

Inclusion Criteria:

1. Women able to give informed consent

2. Women having uterine imaging

Exclusion Criteria:

1. Women currently pregnant

2. Allergy to either gadolinium or iodinated contrast

3. Severe claustrophobia

4. Weight in excess of 250 pounds

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Acquisition of MR elastography images for comparison.

Outcome Description:

MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging(MRI) protocol.

Outcome Time Frame:

every six months

Safety Issue:


Principal Investigator

David A. Woodrum, M.D., PhD.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic-Rochester, Minnesota


United States: Institutional Review Board

Study ID:




Start Date:

October 2010

Completion Date:

July 2013

Related Keywords:

  • Uterine Fibroids
  • Uterine fibroids
  • Uterine leiomyomas
  • MR Elastography
  • MRI (Magnetic Resonance Imaging)
  • Symptomatic Uterine Fibroids
  • Leiomyoma
  • Myofibroma



Mayo ClinicRochester, Minnesota  55905