Pilot Study of In-Room PET in Proton Radiation Therapy
- Depending upon when the participant enrolls in the study, they will have anywhere from
1 to 4 in-room PET scans during proton radiation treatment. There are three groups.
- Group 1: A total of 24 participants in the study will have a PET scan right after their
first radiation treatment is completed. The scan will take 15-20 minutes. For 5 of
the first 19 participants, the PET scan will be performed three more times within a
week (Monday, Wednesday, Friday). For participants 20-24 the scan will be performed
three times in the 1st, 3rd and 5th weeks.
- Group 2: Three participants will have a 20 minute PET scan done after the first dose of
radiation given to the tumor.
- Group 3: Three participants will have a 5-20 minute PET scan done after the delivery of
the first dose of radiation, and a 15-20 minute PET scan will be done after the
delivery of the second dose of radiation.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Acquire PET scan data in list-mode on patients undergoing external beam proton radiotherapy for brain and soft tissue tumors in head. Analyze these data to assess the effectiveness of using NeuroPET for in-room PET monitoring or proton radiation therapy quality assurance.
Helen A. Shih, MD
Massachusetts General Hospital
United States: Institutional Review Board
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|