Prospective Study of Changes in Brown Adipose Tissue (BAT) Activity in Men Receiving Androgen Deprivation Therapy (ADT) With a GnRH Agonist or Antagonist for Prostate Cancer
- Participants will be asked to come into the clinic for additional visits before they
begin hormone therapy. The following procedures will be performed: Cold-activated
PET/CT scan; body composition DXA scan; blood tests, questionnaires and abdominal fat
- During hormone therapy, the participant will return to the clinical once after 3
months, and again after 6 months, to draw blood for laboratory tests.
- After 12 months of hormone therapy, the participant will return to teh clinic to repeat
the following procedures: Cold-activated PET/CT scan; body composition DXA scan; blood
tests; questionnaires and abdominal fat biopsy.
Observational Model: Case-Only, Time Perspective: Prospective
Change in brown adipose tissue activity
To assess the change in cold-activated borwn adipose tissue (BAT) activity upon initiation of GnRH agoinist or antagoinist therapy among men treated for prostate cancer. The primary endpoint is percent change in cold-activated BAT volumne after 12 months of treatment.
Philip J Saylor, MD
Massachusetts General Hospital
United States: Institutional Review Board
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|