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Selenium Status Measured in Blood After a Higher Intake of Fish and Shellfish - a Randomized Dietary Intervention Study


Phase 1
50 Years
74 Years
Not Enrolling
Both
Selenium Status, Selenium Uptake From Fish and Shellfish

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Trial Information

Selenium Status Measured in Blood After a Higher Intake of Fish and Shellfish - a Randomized Dietary Intervention Study


Selenium is an essential trace element that is incorporated into proteins in the human body
and it hereby plays a major role in several important cellular processes. Previous studies
have indicated that the selenium status of the Danish population is below the levels
required to optimize the suggested protective effects of selenium towards major diseases
including cancer. In Denmark, important natural sources of selenium are fish and shellfish.


Inclusion Criteria:



- men and women

- 50-74 years

- BMI 18.5-28 kg/m2

- non-smokers

Exclusion Criteria:

- strenuous exercise > 10 h/week

- excessive intake of alcohol

- frequent intake of fish and shellfish > 200-300 g/week

- intake of dietary supplements 3 months before or during the study

- frequent use of medication except antihypertensive medicine, cholesterol lowering
medicine and hormone replacement medicine

- simultaneous participation in other research projects

- cancer diagnosis within the past 5 years

- severe chronic diseases

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

Selenium concentration in whole blood

Outcome Time Frame:

Measured at baseline

Safety Issue:

No

Principal Investigator

Anne Tjonneland, professor, M.D., Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Institute of Cancer Epidemiology, Danish Cancer Society

Authority:

Denmark: The Regional Committee on Biomedical Research Ethics

Study ID:

DCS-53227244

NCT ID:

NCT01224249

Start Date:

August 2010

Completion Date:

March 2011

Related Keywords:

  • Selenium Status
  • Selenium Uptake From Fish and Shellfish
  • Selenium
  • Selenoprotein P
  • Fish
  • Shellfish
  • Bioavailability

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