Inclusion Criteria:

1. Provision of signed written informed consent.

2. Histologically or cytologically confirmed diagnosis of advanced solid tumor.

3. Age ≥ 18 years.

4. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2.

5. Life expectancy of ≥ 12 weeks.

6. Disease measurability:

Patients must have a measurable - as per Response Evaluation Criteria in Solid
Tumours (RECIST) criteria version 1.1 - and/or evaluable disease.

7. Paraffin-embedded archival tumor tissue available. Fresh biopsies will be required if
no paraffin embedded tumor tissues available.

8. Adequate bone marrow function.

9. Adequate cardiac function: Patient should have Left Ventricular Ejection Fraction
(LVEF) of ≥ 50% as determined by echocardiography (ECHO) or Multi Gated Acquisition
(MUGA) scans.

10. Adequate liver function.

11. Adequate renal function.

12. Adequate adrenal function assessed by baseline cortisol of > 200 nmol/L

13. Ability to comply with protocol requirements.

14. Female patients must be postmenopausal (12 months of amenorrhea), surgically sterile
or they must agree to use a physical method of contraception. Male patients who have
been sterilized must agree to use a barrier method of contraception. Male subjects
must also commit to use a barrier method of contraception until at least 3 months
after the end of study treatment.

15. Female patients of child-bearing potential must have a negative serum pregnancy test
within the seven days prior to the first study drug administration.

Exclusion Criteria:

1. History of allergic reactions attributed to components of the formulated product.

2. Inability to swallow oral medications or impaired gastrointestinal absorption due to
active inflammatory bowel disease.

3. Known Central Nervous System (CNS) metastases or leptomeningeal metastases will be
eligible only if it could be radiologically demonstrated that there is no CNS disease
progression during the 3 months prior to the study

4. Known active or uncontrolled pulmonary dysfunction.

5. Uncontrolled hypertension

6. Prior chemotherapy, radiotherapy (other than short cycle of palliative radiotherapy
for bone pain), or immunotherapy within 28 days of first receipt of study drug
(within 6 weeks for nitrosoureas and mitomycin C). Hormone therapy within 14 days of
first receipt of study drug, with exception of prostate cancer if indicated.

7. Prior toxicities from chemotherapy or radiotherapy which have not regressed to Grade
≤ 1 severity - National Cancer Institute Common Terminology Criteria for Adverse
Events (NCI-CTCAE version 4.0).

8. Type 1 or 2 diabetes mellitus requiring regular medication and/or a fasting plasma
glucose (FPG) ≥ 120 mg/dL (or 6.6 mmol/dL) at screening.

9. Increased QTc interval (QTc > 450 ms for male; > 460 ms for female).

10. History of heart failure, refractory hypokalemia to adequate supplementation, family
history of long QT syndrome or other risk factors for "Torsades de Pointes", and/or
the use of concomitant medications that prolong the QT/QTc interval.

11. Prior corticosteroid therapy within 14 days of first receipt of study drug.

12. Treatment with any investigational agent within 28 days of first receipt of study
drug.

13. Acute or chronic infection. Any other diseases, metabolic dysfunction, physical
examination finding, or clinical laboratory finding or any other medical condition
that, in the opinion of the investigator, contraindicates the use of an
investigational drug, or will impose excessive risk to the patient.

14. Known Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C
Virus (HCV) infection.

15. History of clinically significant bowel disease including abdominal fistula,
gastro-intestinal perforation, and diverticulitis.

16. Major surgery within 28 days of first receipt of study drug.

17. Pregnant or lactating women

18. Altered mental status or psychiatric disorder that, in the opinion of the
investigator, would preclude a valid patient informed consent.