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The Impact of Adnexal Involvement of the Severity and Prognosis of Chronic Graft-versus-Host Disease


N/A
N/A
N/A
Open (Enrolling)
Both
Graft vs Host Disease, Chronic Graft vs Host Disease, cGVHD

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Trial Information

The Impact of Adnexal Involvement of the Severity and Prognosis of Chronic Graft-versus-Host Disease


- At the initial visit, participants will have a complete examination of their skin, hair
and nails. We will also test muscle strength and movement by moving the participant's
arms, legs and neck. Photographs will be taken of the skin, hair and nails of they are
abnormal. Blood tests will be done to check the liver and blood cell count. The
participant and their legal guardian will answer questions about how the participant
feels and about their health.

- Participants will then be scheduled for follow up visits at 3 months, 6 months, and 12
months. At each subsequent visit the following will be done: A complete examination of
the skin, hair and nails; a test of muscle strength; photographs will be repeated;
blood tests to check liver and blood cell counts; and questions about how the
participant feels and about their health.


Inclusion Criteria:



- Received hematopoietic stem cell transplant

- Meet the diagnostic criteria for cutaneous cGVHD

Exclusion Criteria:

- Previous HSCT (other then the current HSCT)

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Adnexal involvement

Outcome Description:

To determine if adnexal involvement predicts worse severity and/or prognosis in chronic GVHD. This will be measured by administration of systemic therapy other than steroids.

Outcome Time Frame:

1 year

Safety Issue:

No

Principal Investigator

Jennifer Huang, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Children's Hospital Boston

Authority:

United States: Institutional Review Board

Study ID:

10-163

NCT ID:

NCT01221766

Start Date:

September 2010

Completion Date:

Related Keywords:

  • Graft Vs Host Disease
  • Chronic Graft vs Host Disease
  • cGVHD
  • adnexal
  • hair and nail
  • chronic graft vs host disease
  • children
  • Graft vs Host Disease

Name

Location

Dana-Farber Cancer InstituteBoston, Massachusetts  02115
Children's Hospital BostonBoston, Massachusetts  02115