Inclusion Criteria:

- histologically or cytologically proven unresectable advanced or metastatic biliary
tract cancer (including intrahepatic and extrahepatic CC and gallbladder cancer)

- age ≥ 18 years

- ECOG performance status ≤ 2

- bidimensionally measurable disease per RECIST criteria

- no prior chemotherapy or targeted therapy for advanced disease

- adequate bone marrow reserve (neutrophil count > 1500 /µL, platelet count > 100,000
/µL)

- adequate renal function (serum creatinine ≤ 1.5 x the upper limit of normal)

- adequate hepatic function (serum bilirubin <2.5 x the upper limit of normal (ULN)
and serum transaminase level of ≤ 5 x ULN)

- written informed consent

Exclusion Criteria:

- prior palliative treatment

- resectable disease

- brain metastases

- serious or uncontrolled concurrent medical illness

- pregnancy or nursing

- history of other malignancies with the exception of excised cervical or basal
skin/squamous cell carcinoma

- peripheral neuropathy (grade > 1)