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Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples


N/A
18 Years
70 Years
Not Enrolling
Both
Neuroendocrine Carcinoma (Carcinoid)

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Trial Information

Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples


Patient group: patients with neuroendocrine tumors (active or inactive) Healthy volunteers


Patients:

Inclusion Criteria:



- having neuro-endocrine disease

Exclusion Criteria:

- age below 18 or above 70 years

- prostate cancer

- kidney failure (estimated GF < 30 mL/Min)

- heart failure

- chronic atrophic gastritis

- pregnancy

Healthy subjects:

Inclusion Criteria:



- healthy

Exclusion Criteria:

- age below 18 or above 70 years

- taking any chronic medication (except OCP)

- prostate cancer

- kidney failure (estimated GFR < 30 mL/min)

- heart failure

- pheochromocytoma

- islet cell tumors

- medullary thyroid cancer

- essential hypertension

- neurofibromatosis

- use of proton pump inhibitors

- chronic atrophic gastritis

- pregnancy

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

chromogranin A concentration serum

Outcome Description:

For determination of normal CgA range, we will recruit 60 healthy subjects (30 female, 30 male), in whom a single plasma sample will be obtained for measurement of CgA B For determination of CgA in patients with carcinoid disease (active or inactaive), we wil recruit 200 patients with carcinoid disease from our local neuroendocinre oncology clinic.

Outcome Time Frame:

single time

Safety Issue:

No

Principal Investigator

Stan Van Uum, MD PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Western Ontario, Canada

Authority:

Canada: Health Canada

Study ID:

HSREB16279

NCT ID:

NCT01216267

Start Date:

June 2010

Completion Date:

January 2012

Related Keywords:

  • Neuroendocrine Carcinoma (Carcinoid)
  • chromogranin A
  • neuroendocrine
  • carcinoid
  • Proton Pump Inhibitor
  • Carcinoid Tumor
  • Carcinoma
  • Carcinoma, Neuroendocrine

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