Inclusion Criteria:

- adult patients, >=18 years of age;

- metastatic pancreatic cancer (adenocarcinoma);

- good liver, kidney, and bone marrow function.

Exclusion Criteria:

- previous systemic treatment for metastatic pancreatic cancer;

- pregnant or lactating females;

- fertile men, or women of childbearing potential, not using adequate contraception;

- major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to study treatment start;

- current or recent treatment (within 30 days prior to starting study treatment) with
another investigational drug, or participation in another investigational study.