Early Detection of Anthracycline Cardiotoxicity by Echocardiographic Analysis of Myocardial Deformation in 2D Strain
Analysis of myocardial deformation in its longitudinal component, circumferential and
radial, is a new echocardiographic technique for evaluating myocardial function, which has
demonstrated its superiority compared to LVEF in many clinical situations. It therefore
seems promising to evaluate this new tool in the earlier detection of adverse myocardial
chemotherapy with anthracyclines. The ultimate goal is indeed to determine a reliable and
reproducible parameter for cardiac toxicity diagnostic to avoid chemotherapy interruption,
thus improving the survival of these patients.
The main objective of this project is to evaluate the association between changes in
myocardial deformation longitudinal 2D strain echocardiography between baseline and 6 weeks
after initiation of anthracycline therapy for acute leukemia and the occurrence of impaired
left ventricular function within 12 months after starting treatment.
It is a prognostic study of clinical-looking, without randomization. The inclusion will take
place over a period of 12 months with a total follow-up of 12 months.
The analysis will focus on the identification of parameters predictive of alteration of Fe
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
determination of longitudinal myocardial deformation by echography with 2D strain analysis after 6 weeks of anthracycline chemotherapy.
Stéphane Lafitte, MD-PhD
University Hospital Bordeaux, France
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)