Inclusion Criteria

INCLUSION STUDY CRITERIA:

- Males and females 21 years of age or older Non-specific, mechanical predominantly
axial CLBP (subjects with below the knee pain included when the LBP component was 50%
or more than the overall pain component)

- Pain for at least 3 months, with a minimum average daily pain score of 4 on a 0-10
NRS MRI evidence of disc degeneration and changes consistent with the diagnosis of
degenerative disc disease or spondylotic disease of the spine.

EXCLUSION STUDY CRITERIA:

- Prior back surgery, compression fracture(s), cancer as possible cause of back pain
Clinically relevant radiculopathic pain,

- MRI evidence of frank DISK HERNIATION or any other abnormality or pathology regarded
as the probable cause of the patient's pain.

- Defect or fracture of a pars interarticularis, spondylolisthesis with greater than 4
mm of misalignment Having a glomerular filtration rate (GFR) less than 60
ml/min/1.73m 2 .

- Hypocalcemia, significant cardiac, hematological, renal, hepatic, metabolic,
endocrinological disease

- Being pregnant or nursing

- Receiving Worker's Compensation, having a pending legal claim

- Weighing less than 45 kg

- Subjects who score 26 and above on the Beck Depression Inventory

- Prior pamidronate treatment patients who in the opinion of the study physician have
poor oral hygiene, do not have regular dental care, had a tooth extraction or another
invasive dental procedure within 3 months prior to study enrollment