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A Pilot Study of Radiation Toxicity in the Liver Using MRI-Based Perfusion

18 Years
Open (Enrolling)
Liver Cancer

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Trial Information

A Pilot Study of Radiation Toxicity in the Liver Using MRI-Based Perfusion

Inclusion Criteria:

- Patients must be ≥18 years of age.

- The patient's planned cancer management is radiation to the liver with or without

- Patients must have a performance status of 0-2 and a life expectancy of at least 3

- Patients should have no contraindications to having a contrast enhanced MRI scan.

Exclusion Criteria:

- Women who are pregnant or breastfeeding are excluded.

- Prisoners are excluded

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Measure of Liver Function Before, During and After Radiation

Outcome Description:

The primary objective of this research is to assess how a course of radiation therapy changes the way blood flows through the liver. Researchers want to use the information collected from this research for future research, to see if this change in blood flow indicates that an individual patient is at higher risk for complications from the radiation therapy, specifically Radiation-Induced Liver Disease (RILD). To be able to do this, the researchers will be using MRI (magnetic resonance imaging) scans completed before, during, and after radiation therapy.

Outcome Time Frame:

2-3 months for treatment; indefinite for follow-up

Safety Issue:


Principal Investigator

Mary Feng, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Michigan Cancer Center


United States: Institutional Review Board

Study ID:

UMCC 2006.067



Start Date:

November 2006

Completion Date:

November 2014

Related Keywords:

  • Liver Cancer
  • Liver Neoplasms
  • Radiation Injuries



University of Michigan Comprehensive Cancer CenterAnn Arbor, Michigan  48109-0752