A Pilot Study of Diffusion MRI in the Assessment of Pancreatic Tumor Response
Patients with pancreatic cancer are treated with combinations of surgery, radiation therapy
and chemotherapy, depending on the location of the cancer and other individual patient
health factors. The goals of therapy are to reduce or eliminate the cancer cells, but
without serious damage to normal cells.Each patient is unique in terms of the cancer type
and location and its sensitivity to treatments. Investigators at The University of Michigan
are conducting a research project to see if treatment effects on an individual patient's
cancer cells can be detected early by new imaging tests in patients with resectable
pancreatic cancer undergoing neoadjuvant chemoradiotherapy. Each patient is unique in terms
of the cancer type and location and its sensitivity to treatments.
Observational Model: Cohort, Time Perspective: Prospective
The goal is to develop a functional imaging method that would be a better predictor of pathological response than the current CT standard. Diffusion MRI has the potential to measure early cellular changes that occur in response to successful therapies, such as chemoradiation, and has been demonstrated to be an early predictor not only of therapeutic response, but also of overall survival for other malignancies.
Mary Feng, MD
University of Michigan Cancer Center
United States: Institutional Review Board
|University of Michigan Cancer Center||Ann Arbor, Michigan 48109|