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Validating the Prognostic Role of ATR Mutation in Patients With Endometrioid Endometrial Cancer


N/A
N/A
N/A
Not Enrolling
Female
Endometrial Cancer

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Trial Information

Validating the Prognostic Role of ATR Mutation in Patients With Endometrioid Endometrial Cancer


OBJECTIVES:

Primary

- To validate the clinicopathologic associations and prognostic significance of ATR
mutation in endometrioid endometrial cancer cases with defective DNA mismatch repair.

OUTLINE: This is a multicenter study.

DNA extracted from previously collected tumor samples is analyzed to validate the
clinicopathologic associations and prognostic significance of ATR mutation.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Women who were eligible and evaluable for the GOG-0210 molecular staging protocol in
women with endometrial cancer

- Women who were registered during the unrestricted enrollment period (through
9/23/07) will automatically qualify

- Women who were registered during the restricted enrollment period (after
9/23/07) will only be considered if needed

- Women who had histologically confirmed endometrioid endometrial adenocarcinoma
regardless of stage or grade

- Women who have defective DNA mismatch repair and are microsatellite instability
positive (MSI+ and MSI-low)

- Women who consented to allow their specimens and clinical data to be used for future
cancer research

- Women who have sufficient high-quality genomic DNA from tumor available for mutation
analysis of ATR

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Overall survival

Safety Issue:

No

Principal Investigator

Israel Zighelboim, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Washington University Siteman Cancer Center

Authority:

Unspecified

Study ID:

CDR0000685834

NCT ID:

NCT01208467

Start Date:

October 2010

Completion Date:

Related Keywords:

  • Endometrial Cancer
  • endometrial adenocarcinoma
  • recurrent endometrial carcinoma
  • stage I endometrial carcinoma
  • stage II endometrial carcinoma
  • stage III endometrial carcinoma
  • stage IV endometrial carcinoma
  • Endometrial Neoplasms
  • Sarcoma, Endometrial Stromal
  • Adenoma

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