Inclusion Criteria:

- Male and female subjects older than 18 years of age

- Histologically confirmed colorectal carcinoma

- Radiological confirmation of unresectable advanced colorectal carcinoma (AJCC Stage
IV) prior to start of initial first-line therapy

- At least one measurable lesion according to RECIST measured within 2 weeks prior to
treatment start in case of partial response or stable disease

- Prior initial first-line therapy included oral or intravenous
fluoropyrimidines/leucovorin,irinotecan or oxaliplatin with or without a standard
dose of bevacizumab lasted between 4.5 and 6 months and finished (last day of last
cycle) within 2 weeks prior to treatment start (treatment duration with irinotecan or
oxaliplatin should not be less than 3 months)

- Patients who achieved disease control measured as objective response or disease
stabilization after initial first-line therapy

- No curative standard therapy is available for the patient after first-line treatment

- ECOG performance status 0-1

- Adequate organ function, hemoglobin ≥ 9 g/L, white blood cell count (WBC) ≥ 3.0 x
109/L, absolute neutrophil count ≥ 1.5 x 109/L, platelets > 100 x109/L, aspartate and
alanine aminotransferase (AST and ALT) ≤ 2.5 x ULN, bilirubin < 1.5 x ULN, blood
creatinine ≤ 1.5 X ULN, prothrombin time (PT) and activated thromboplastin time
(aPTT) within normal range

- Negative pregnancy test in women with childbearing potential

- Expected adequacy of follow-up

- Signed informed consent form (ICF)

Exclusion Criteria:

- More than one line of systemic chemotherapy for metastatic colorectal carcinoma

- Tumor progression after initial first-line therapy

- Clinically significant concomitant diseases or conditions, which in opinion of the
investigator would lead to an unacceptable risk for the subject to participate in the
study

- Prior or current other malignancy, except adequately treated superficial bladder
cancer, basal or squamous cell carcinoma of the skin or other cancer for which the
subject has been disease free for more than 3 years

- Known central nervous system metastases

- Active or uncontrolled infections

- Transfusion-dependent anemia

- History of autoimmune disease or immune deficiency

- Known hypersensitivity to oligonucleotides or excipients of the formulation

- Pregnancy and/or nursing

- Concurrent chronic systemic immune therapy or immunosuppressant medication, including
steroid treatment

- Concurrent chemotherapy, hormonal therapy (except hormonal contraception and hormonal
replacement therapy for menopausal women), or immunotherapy within the last 2 weeks
prior to randomization or during the conduct of the study - Concurrent radiotherapy
within the last 6 months prior to randomization or during the conduct of the study

- Known HIV seropositivity or active hepatitis B or C infection

- Planned major surgery during the study

- Participation in another clinical study with other investigational drugs within 30
days prior to the first treatment day

- Vaccination within 3 months prior to the first treatment day

- Any medical, mental, psychological or psychiatric condition which in opinion of the
investigator would not permit the subject to complete the study or understand the
patient information

- Presence of drug and/or alcohol abuse