Inclusion Criteria:

- Patients must have a confirmed diagnosis of neurofibromatosis 2 by fulfilling
National Institute of Health (NIH) criteria or Manchester criteria, or by detection
of a causative mutation in the NF2 gene

- The NIH criteria (82) includes presence of:

- Bilateral vestibular schwannomas, OR

- First-degree relative with NF2 and EITHER unilateral eighth nerve mass OR
two of the following: neurofibroma, meningioma, glioma, schwannoma,
juvenile posterior subcapsular lenticular opacity

- The Manchester criteria (101) includes presence of:

- Bilateral vestibular schwannomas, OR

- First-degree relative with NF2 and EITHER unilateral eighth nerve mass OR
two of the following: neurofibroma, meningioma, glioma, schwannoma,
juvenile posterior subcapsular lenticular opacity, OR

- Unilateral vestibular schwannoma AND any two of: neurofibroma, meningioma,
glioma, schwannoma, juvenile posterior subcapsular lenticular opacity, OR

- Multiple meningiomas (two or more) AND unilateral vestibular schwannoma OR
any two of: schwannoma, glioma, neurofibroma, cataract

- Patients must have measurable disease, defined as at least one VS >= 1.5 cm (on
longest diameter) as measured by contrast-enhanced cranial MRI scan with fine cuts
through the internal auditory canal (3 mm slices, no skip)

- Life expectancy of greater than 6 months

- ECOG performance status (Karnofsky >= 60% or Lansky Score >= 60)

- Patients must have normal organ and marrow function as defined below:

- Leukocytes >= 3,000/mcL

- Absolute neutrophil count >= 1,500/mcL

- Platelets >= 150,000/mcL or lower limit of institutional normal

- Total bilirubin =< 2 X institutional upper limit of normal

- AST(SGOT)/ALT(SGPT) =< 2.5 X institutional upper limit of normal

- Patients must have recovered from acute toxicity of prior treatment to grade 1 or
less unless otherwise specified

- Patients must have a creatinine clearance or radioisotope GFR >= 60ml/min/1.73 m^2 or
a normal serum creatinine based on age described in the table below:

- Age(years) =< 5: 0.8 mg/dL

- 5 < age (years) =< 10: 1.0 mg/dL

- 10 < age (years) =< 15: 1.2 mg/dL

- Age (years) > 15: 1.5 mg/dL

- Subjects must have a VS not amenable to surgery or have refused surgery due to high
risk for permanent complications related to surgery (e.g. damage to lower cranial
nerve function, facial palsy, risk for cerebrospinal fluid leak, etc.) as determined
by a surgeon with experience in management of NF2 associated VS

- Subjects must have had a discussion of all available treatment options and their
risks and benefits of these options including surgery, radiation therapy,
observation, other clinical trials and expressed their preference for participation
in this trial in the informed consent process

- The effects of bevacizumab on the developing human fetus at the recommended
therapeutic dose are unknown; for this reason and because anti-angiogenic agents are
known to be teratogenic, women of child-bearing potential and men must agree to use
adequate contraception (hormonal or barrier method of birth control; abstinence)
prior to study entry and for the duration of study participation; should a woman
become pregnant or suspect she is pregnant while participating in this study, she
should inform her treating physician immediately

- Ability to understand and the willingness give written informed consent or assent

- Evidence of active disease, defined as progressive hearing loss (with decrease in
word recognition score) related to VS (i.e., not due to prior interventions such as
surgery or radiation) documented in the preceding 24 months with a word recognition
score of < 90% in the target ear

- Proteinuria (including albuminuria) should be screened for by either urine analysis
for urine protein creatinine (UPC) ratio or by urine dipstick; if the UPC ratio is
greater than or equal to 0.5 or if urine dipstick shows 2+ proteinuria, 24-hour urine
protein should be obtained and the level should be < 1000 mg for patient enrollment

Exclusion Criteria:

- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for
nitrosoureas or mitomycin C) prior to entering the study or those who have not
recovered from adverse events due to agents administered more than 4 weeks earlier

- Patients may not be receiving any other investigational agents

- Patients with nervous system tumors associated with NF2 (e.g., schwannomas,
meningiomas, ependymomas, or gliomas) will not be excluded from this clinical trial
as long as these tumors do not require treatment with radiation, surgery, or medical
treatment at the time of enrollment on trial

- Patients with known hypersensitivity of Chinese hamster ovary cell products, other
recombinant human antibodies, or compounds of similar chemical or biologic
composition to bevacizumab

- Inability to tolerate periodic MRI scans or gadolinium contrast without general
anesthesia

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, or psychiatric illness/social situations that would limit compliance with
study requirements

- Clinically significant cardiovascular disease, such as:

- Inadequately controlled HTN (adult subjects: SBP > 160 mmHg and/or DBP > 90 mmHg
despite antihypertensive medication, pediatric subjects: Requirement for
antihypertensive treatment prior to enrollment, or diastolic blood pressure >
95th percentile for age)

- History of CVA within 12 months

- Myocardial infarction or unstable angina within 12 months

- New York heart association grade II or greater congestive heart failure

- Serious and inadequately controlled cardiac arrhythmia

- Significant vascular disease (e.g. aortic aneurysm, history of aortic
dissection)

- Clinically significant peripheral vascular disease

- Pregnant women (positive pregnancy test) are excluded from this study because
bevacizumab is an anti-angiogenic agent with the potential for teratogenic or
abortifacient effects; because there is an unknown but potential risk for adverse
events in nursing infants secondary to treatment of the mother with bevacizumab,
breastfeeding should be discontinued if the mother is treated with bevacizumab; both
fertile men and women must agree to use adequate contraceptive measures during study
therapy and for at least 6 months after the completion of bevacizumab therapy;
abstinence is considered an adequate contraceptive measure

- In the event that a minor (age 12-17) who undergoes a pregnancy test as part of
the screening process receives a positive result, they will be excluded from the
study and their parent(s) of record will be notified of this result

- HIV-positive patients or cancer survivors are eligible for this study if they fulfill
all other eligibility criteria

- Inability to perform volumetric measurement of target VS (e.g., due to the MRI
artifact from auditory brainstem implant or due to presence of collision tumor (two
or more tumors abutting each other) in the cerebellopontine angle); Note: questions
about the ability to perform volumetric analysis on a baseline MRI scan should be
directed to the study radiologist, Dr. Gregory Sorensen

- Concurrent use of anti-coagulant drugs (not including prophylactic doses), history of
coagulopathy, or evidence of bleeding diathesis or coagulopathy

- Imaging (CT or MRI) evidence of newly identified hemorrhage (new within the last in
the 6 months prior to enrollment), any history of symptomatic intracranial
hemorrhage, or any history of spontaneous intracranial hemorrhage

- Serious or non-healing wound, ulcer or bone fracture

- History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess
within 6 months prior to day 1

- Invasive procedures defined as follows:

- Major surgical procedure, open biopsy or significant traumatic injury within 28
days prior to Day 1 therapy

- Brain biopsy within 28 days prior to day 1 of therapy (wounds must be fully
healed from brain biopsies performed more than 28 days prior to day 1 of
therapy)

- Anticipation of need for major surgical procedures during the course of the
study

- Core biopsy within 7 days prior to D1 therapy

- Prior treatment with bevacizumab or other VEGF targeting therapies

- Personal history of autoimmune coagulopathy, including idiopathic thrombocytopenia
purpura (ITP)