Absorption of "ABH Gel" (Ativan®, Lorazepam; Benadryl®, Diphenhydramine; and Haldol®, Haloperidol Gel) From the Skin of Normal Volunteers
OBJECTIVES:I. To study the absorption of the three components in the topical ABH gel in 10
healthy volunteers, and determine if there are any adverse effects. OUTLINE: Patients apply
lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes.
After completion of study treatment, patients are followed up for 5 hours.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Lorazepam, Diphenyhydramine, Haloperidol Absorption
Level of lorazepam absorption measured by the serum concentration of the drug
Virginia Commonwealth University
United States: Federal Government
|Virginia Commonwealth University/Massey Cancer Center||Richmond, Virginia 23298|