Hypoxia Diagnosis and Evaluation Using F-MISO PET and Biomarkers in Brain Tumors
Interventional
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
hypoxia volume (HV) and degree (maximum ratio [Rmax]) defined from 18F-FMISO uptake rates
determine, in vivo, the hypoxic character of tumours from a PET biomarker. Tumoral hypoxia will be characterized by hypoxia volume (HV) and degree (maximum ratio [Rmax]) defined from 18F-FMISO uptake rates characterize the link between the tumoral hypoxia and the hypoxic and angiogenic factor expressions that favour vascular neoformation and proliferation feeding tumoral cells
PET 18F-MISO between Day 1 & Day 7
No
GUILLAMO Jean Sébastien, MD, PhD
Principal Investigator
University Hospital, Caen
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
2009-015543-16
NCT01200134
October 2010
July 2012
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