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Prospective Characterization of Tumor-specific T-cell Immunity in Muscle-invasive Bladder Cancer and Its Correlation With Clinical Parameters


N/A
18 Years
90 Years
Open (Enrolling)
Both
Bladder Cancer

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Trial Information

Prospective Characterization of Tumor-specific T-cell Immunity in Muscle-invasive Bladder Cancer and Its Correlation With Clinical Parameters


Inclusion Criteria:



- Histologically confirmed muscle-invasive urothelial carcinoma

- Age > 18 years

- Hemoglobin > 10g/dl

- Signed Informed Consent

- Karnofsky index < 70%

Exclusion Criteria:

- Clinically relevant second malignancy

- Severe comorbidities (e.g. NYHA III, end-stage renal disease)

- Chronic infectious disease (HIV, Tuberculosis)

- Immunosupression

- Severe psychiatric diseases

- Blood donation in the last 4 weeks

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Thomas Horn, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Urology, Technische Universit√§t M√ľnchen

Authority:

Germany: Local ethics commission

Study ID:

IBT-1

NCT ID:

NCT01198808

Start Date:

August 2010

Completion Date:

Related Keywords:

  • Bladder Cancer
  • Bladder cancer
  • chemotherapy
  • T cells
  • Immunotherapy
  • Tumor-specific immunity in bladder cancer
  • Urinary Bladder Neoplasms

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