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The Relationship of Racial Genetic Admixture With Endometrial Cancer Outcomes


N/A
N/A
N/A
Not Enrolling
Female
Endometrial Cancer

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Trial Information

The Relationship of Racial Genetic Admixture With Endometrial Cancer Outcomes


OBJECTIVES:

Primary

- To identify racial categorization as the proportion of genetic background of
African-American or European-American women with endometrioid endometrial cancer (EEC).

- To evaluate the association of racial genetic admixture with clinicopathologic
variables and outcomes.

Secondary

- To compare the concordance between racial genetic admixture and self-designated race
categorization.

OUTLINE: This is a multicenter study. Patients are stratified by race (African-American vs
European-American) and disease stage (I vs II vs III vs IV).

DNA from archived frozen normal tissue samples are genotyped for the ancestry informative
markers. Clinicopathological and demographic characteristics associated with each sample are
also collected.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologically confirmed endometrial cancer

- Stage I-IV disease regardless of grade

- Underwent surgical staging including hysterectomy, bilateral oophorectomy,
washings, and pelvic lymphadenectomy

- Eligible and evaluated on GOG-0210 clinical trial, a Molecular Staging Study in
Endometrial Cancer

- Available frozen or formalin-fixed and paraffin-embedded normal tissue that is free
of tumor cells and yields sufficient high-quality normal DNA for testing

PATIENT CHARACTERISTICS:

- Consented their specimens and clinical data to be collected and used in future
studies

- Self-declared African-American or Caucasian race

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Proportion of genetic background that is of African-American descent

Safety Issue:

No

Principal Investigator

Rodney P. Rocconi, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of South Alabama Mitchell Cancer Institute

Authority:

Unspecified

Study ID:

CDR0000684547

NCT ID:

NCT01198171

Start Date:

October 2010

Completion Date:

Related Keywords:

  • Endometrial Cancer
  • stage I endometrial carcinoma
  • stage II endometrial carcinoma
  • stage III endometrial carcinoma
  • stage IV endometrial carcinoma
  • Endometrial Neoplasms
  • Sarcoma, Endometrial Stromal
  • Adenoma

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