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Médulloblastome of the Child and After-effects Cognitive: Study Anatomo-functional by IRM of the Working Memory

8 Years
12 Years
Open (Enrolling)
Child Cancer Brain

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Trial Information

Médulloblastome of the Child and After-effects Cognitive: Study Anatomo-functional by IRM of the Working Memory

The functional study should make it possible to show the specifically committed networks
according to the cognitive tasks. Among patients, the relative difficulty to carry out the
tasks of working memory should be accompanied by a recruitment of the dorso-side cortex
préfrontal, lower and parietal frontal cortex but also of the median frontal areas such as
the additional driving surface, the former cingulum. Moreover, one deterioration of the
engagement of the cérébello-cerebral network (left lower parietal cortex and cérébelleux
cortex lower right) facilitating the execution of these tasks should be observed.

Inclusion Criteria:

- Old from 8 to 12 years

- Total IQ > 70 for the participation in the study and/or age développemental 7 years

- Treaties for a médulloblastome after the 6 years age in remission supplements with 6
months a minimum time compared to the end of all the treatments

- Followed within the framework of the protocol of evaluation of the mnemic and
attentionnelles after-effects

- Sensory after-effects compatible with the realization of the tasks and good
performances at the time of the preceding drive the IRM

- Absence of counter-indication to the IRM

- Absence of catch of méthylphénidate (Ritaline®) for the treatment of disorders
attentionnels 48h before the IRM

- Enlightened assent signed by at least one of the two parents or holders of the
parental authority and by the child (minor)

Exclusion Criteria:

- Agitation or movements of the head at the time the IRM

- Artifacts of magnetic susceptibility in projection of the areas of interest
(intracranial haemorrhage, cortical and/or metal remains post-operative) • Bad
execution of the cognitive tasks

- Tumoral relapse in the course of protocol

Type of Study:


Study Design:

Observational Model: Case Control

Principal Investigator

Anne A PAGNIER, Doctor

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Hospital, Grenoble


France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:




Start Date:

October 2007

Completion Date:

July 2012

Related Keywords:

  • Child Cancer Brain
  • child cancer brain