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Adipose Tissue Gene Expression Profiles in Women With PCOS Versus Controls Matched for BMI

18 Years
40 Years
Not Enrolling
Polycystic Ovary Syndrome

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Trial Information

Adipose Tissue Gene Expression Profiles in Women With PCOS Versus Controls Matched for BMI

Adipose tissue is a central organ in mediating metabolic health. There is some evidence that
women with polycystic ovary syndrome (PCOS) have a degree of adipose tissue dysfunction
which may negatively affect their metabolic health. The aim of this study was to assess
transcriptomic profiles of subcutaneous adipose tissue of women with PCOS in comparison with
a control population matched on the basis of age and body mass index (BMI). A secondary aim
was to then relate these gene expression profiles to the biochemical environment.

Inclusion Criteria:

- Had a positive diagnosis of PCOS as defined according to the NIH criteria as chronic
oligomenorrhoea (< 9 menstrual cycles per year) and clinical and/or biochemical
evidence of hyperandrogenism, in the absence of other disorders causing the same
phenotype. Clinical criteria included hirsutism with a Ferriman-Galwey score greater
than 9, acne or male pattern alopecia; biochemical criteria included
total-testosterone, androstenedione or dehydroepiandrosterone sulphate (DHEAS)
greater than the laboratory reference range.

- Were between the ages of 18 and 40

Exclusion Criteria:

- Were under 18 years or greater than 40 years old,

- Were non-Caucasian

- Were pregnant, lactating or trying to conceive

- Had a body mass index (BMI) <18kg/m2 or >50kg/m2

- Had a recent illness or any chronic illness likely to influence results

- Were taking hormonal contraception

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Outcome Measure:

Transcriptomic profiling of subcutaneous adipose tissue of women with PCOS and age and BMI matched controls

Outcome Description:

Gene expression profiles from women with PCOS and controls matched for age and BMI were determined by microarray analysis of whole subcutaneous adipose tissue samples. Single gene changes as well as pathway analyses will be used to determine differently expressed genes and pathways between the PCOS cohort and controls.

Outcome Time Frame:

Recruitment ran from Dec 2007-July 2008. Subjects attended the study location fasting on one occasion

Safety Issue:


Principal Investigator

James Gibney, Dr

Investigator Role:

Principal Investigator

Investigator Affiliation:

The Adelaide and Meath Hospital


Ireland: Research Ethics Committee

Study ID:




Start Date:

December 2007

Completion Date:

July 2008

Related Keywords:

  • Polycystic Ovary Syndrome
  • PCOS
  • Polycystic Ovary Syndrome