Adipose Tissue Gene Expression Profiles in Women With PCOS Versus Controls Matched for BMI
Adipose tissue is a central organ in mediating metabolic health. There is some evidence that
women with polycystic ovary syndrome (PCOS) have a degree of adipose tissue dysfunction
which may negatively affect their metabolic health. The aim of this study was to assess
transcriptomic profiles of subcutaneous adipose tissue of women with PCOS in comparison with
a control population matched on the basis of age and body mass index (BMI). A secondary aim
was to then relate these gene expression profiles to the biochemical environment.
Observational Model: Case Control, Time Perspective: Cross-Sectional
Transcriptomic profiling of subcutaneous adipose tissue of women with PCOS and age and BMI matched controls
Gene expression profiles from women with PCOS and controls matched for age and BMI were determined by microarray analysis of whole subcutaneous adipose tissue samples. Single gene changes as well as pathway analyses will be used to determine differently expressed genes and pathways between the PCOS cohort and controls.
Recruitment ran from Dec 2007-July 2008. Subjects attended the study location fasting on one occasion
James Gibney, Dr
The Adelaide and Meath Hospital
Ireland: Research Ethics Committee