Impact of Intraoperative Protective One-lung Ventilation in Patients Undergoing Esophagectomy : a Prospective Randomized Controlled Trial
Large tidal volume are known risk factor of acute lung injury.Mechanical ventilation with
low tidal volume has been shown to attenuate lung injuries in critically ill
patients.Esophagectomy surgery need a relatively long time of one-lung ventilation. A normal
tidal volume of two-lung ventilation should be a large one when exerted to one lung. We
hypothesized that low tidal volume ventilation during one-lung ventilation could decrease
incidence rate of postoperative acute lung injury and mortality.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
cytokines of bronchoalveolar lavage
TNF-a,IL-1b,IL-6,IL-8 of BAL will be measured with enzyme-linked immunoassay,all markers will be reported with a unit of pg/ml
10 minutes before surgery ,at the end of surgery immediately
Yes
Zhanggang Xue, professor
Study Director
Shanghai Zhongshan Hospital
China: Ministry of Health
ESO-2010-LV
NCT01194895
August 2010
March 2013
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