Inclusion Criteria:

- Patients must have histologically or cytologically confirmed non-small cell lung
cancer that is incurable (stage IV or malignant effusion or recurrent)

- Patients must have measurable disease, defined as at least one lesion that can be
accurately measured in at least one dimension (longest diameter to be recorded) as >=
10 mm with CT scan with cuts at 2.5 or 5 mm

- Patients must have tumor amenable to core biopsy (or by incisional, excisional or
punch biopsy) for research purposes; the collaborating interventional radiologists
will make the determination whether or not the patient has a tumor amenable to biopsy
and whether or not the patient is medically an appropriate candidate for tumor biopsy

- The patient must have received front line cytotoxic chemotherapy (combination or
single agent, with or without the addition of targeted agents) for advanced NSCLC

- Patients will be eligible whether or not they have had a response or stable disease
or progression of tumor on the front line cytotoxic therapy, and whether or not they
have tumor progression in the interval between their front line therapy and
initiation of therapy on this study

- Patients will also be eligible if they have received maintenance cytotoxic
chemotherapy (eg pemetrexed) following completion of the front line chemotherapy,
provided there had not been tumor progression between the end of the front line
chemotherapy and the initiation of the maintenance chemotherapy

- Patients may also have received prior adjuvant chemotherapy or chemoradiotherapy with
curative intent (followed by tumor recurrence or progression) before being given the
front line therapy for advanced disease

- The last planned front-line therapy cycle or maintenance therapy cycle must have been
administered >= 3 weeks (or >= 6 weeks after last therapy if it included a
nitrosourea or mitomycin-C) and =< 8 weeks prior to initiation of therapy on this
study, although they may be registered on study (prior to drug administration) any
time from 0-8 weeks after last planned front-line chemotherapy (to permit correlative
studies to be arranged before therapy starts)

- ECOG performance status =< 2 (Karnofsky >= 60%)

- Leukocytes >= 3,000/mcL

- Absolute neutrophil count >= 1,000/mcL

- Platelets >= 100,000/mcL

- Total bilirubin within normal institutional limits

- AST(SGOT) and ALT(SGPT) =< 3 X institutional upper limit of normal

- Creatinine =< 1.5 X institutional upper limit of normal

- Hemoglobin ≥ 9 g/dL

- Since all patients on this study will undergo tumor biopsy, the patient must have
coagulation parameters in keeping with guidelines used by the Department of
Interventional Radiology at MD Anderson Cancer Center to decide whether or not a
patient is suitable for biopsy; specifically, the patient must have an INR =< 1.7 x
upper limit of normal (ULN), and the patient must not have received aspirin or
coumadin within the previous week or a therapeutic dose of a heparin product within
the previous 24 hours

- The effects of RO4929097on the developing human fetus at the recommended therapeutic
dose are unknown; for this reason and because Notch signal pathway inhibitors are
known to be teratogenic, women of childbearing potential must use two forms of
contraception (i.e., barrier contraception and one other method of contraception)
from at least 4 weeks prior to initiation of therapy on this study, for the duration
of study participation, and for at least 2 months post-treatment; while it is unknown
how long after last drug administration drug that remains in the body would pose a
risk to a subsequent pregnancy, the plasma half-life of the drug would suggest that
it would probably only be for a few days; should a woman become pregnant or suspect
she is pregnant while she or her partner are participating in this study and for 2
months after study participation, the patient should inform the treating physician
immediately

- Women of childbearing potential are required to have a negative serum pregnancy test
(with a sensitivity of at least 25 mIU/mL) within 10-14 days and within 24 hours
prior to the first dose of RO4929097 (serum or urine); following initiation of
therapy with RO4929097, a pregnancy test (serum or urine) will be administered every
3 weeks while on study; a positive urine test must be confirmed by a serum pregnancy
test; prior to dispensing RO4929097, the investigator or designate must confirm and
document the patient's use of two contraceptive methods, dates of negative pregnancy
test, and confirm the patient's understanding of the teratogenic potential of
RO4929097

- Patients with lung cancer may have false-positive pregnancy tests due to production
of beta-HCG by tumor; patients with a positive pregnancy test who are unlikely to be
pregnant may be considered for entry on this trial if they are deemed to be unlikely
to be pregnant by an obstetrician or gynecologist and if the study sponsor is in
agreement with their study entry

- Female patients of childbearing potential are defined as patients to whom any of the
following apply:

- Patients with regular menses

- Patients, after menarche with amenorrhea, irregular cycles, or using a
contraceptive method that precludes withdrawal bleeding

- Women who have had tubal ligation

- Female patients may be considered to NOT be of childbearing potential for the
following reasons:

- The patient has undergone total abdominal hysterectomy with bilateral
salpingo-oophorectomy or bilateral oophorectomy

- The patient is medically confirmed to be menopausal (no menstrual period) for 24
consecutive months

- Since there is a very small possibility that RO4929097 would reach high enough
concentrations in semen of men participating in this study to pose a threat to a
fetus being carried by their sexual partner, men participating in the study must also
use 2 methods of contraception including 1 barrier method from the time of initiation
of therapy on the study until 2 months after their last treatment on the study if
their sexual partner has childbearing potential; if their sexual partner is already
pregnant, 1 barrier method must be used to minimize the probability of exposure of
the fetus to potentially toxic concentrations of RO4929097; while teratogenicity from
exposure of a fetus to a drug in semen is a theoretical possibility, there has been
little documentation of this for any agent in humans, and it has been documented in
animals primarily only if the drug is present in semen at the time of fertilization;
in addition, it is unknown how long the drug might remain detectable in semen;
although the plasma half-life of the drug would suggest that its level in seminal
fluids would probably be very low by a few days after last drug administration

- Because there is an unknown but potential risk for adverse events in nursing infants
secondary to treatment of the mother with RO4929097, breastfeeding should be
discontinued if the mother is treated with RO4929097

- With respect to patients with brain metastases, most drugs assessed reach
concentrations in brain metastases or in primary brain tumors that are comparable to
those in other tumor sites (although this has not yet been tested for RO4929097);
furthermore, lung cancer brain metastases have response rates to systemic therapy
that are comparable to response rates in metastases in other sites, after correcting
for number of organ systems involved by tumor, survival is not substantially
different for advanced NSCLC patients with vs without brain metastases, and risk of
symptomatic CNS hemorrhage is not substantially higher in NSCLC patients with vs
without brain metastases; brain metastases are very common in NSCLC; hence, patients
with asymptomatic or minimally symptomatic brain metastases are eligible for this
trial provided it is not anticipated that they will require any of the following over
the course of their participation in the trial:

- Corticosteroids for control of cerebral edema

- Enzyme-inducing anticonvulsants

- Radiotherapy, surgery or other local therapy for the brain metastases

- Patients must be able to swallow tablets

Exclusion Criteria:

- Patients may be registered on the protocol any time from 0-8 weeks after
administration of last front-line therapy or maintenance therapy, but should not
receive their first treatment on this study until 3-8 weeks after administration of
last front-line therapy or maintenance therapy (or 6-8 weeks for prior nitrosoureas
or mitomycin-C), and must have recovered adequately from adverse events to meet other
eligibility criteria

- Patients may not be receiving any other investigational agents

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to RO4929097 or other agents used in the study

- Patients taking medications with narrow therapeutic indices that are metabolized by
cytochrome P450 (CYP450), including warfarin sodium (Coumadin®) are ineligible

- Preclinical studies indicate that RO4929097 is a substrate of CYP3A4 and inducer of
CYP3A4 enzyme activity; caution should be exercised when dosing RO4929097
concurrently with CYP3A4 substrates, inducers, and/or inhibitors; furthermore,
patients who are taking concurrent medications that are strong inducers/inhibitors or
substrates of CYP3A4 should be switched to alternative medications to minimize any
potential risk; if such patients cannot be switched to alternative medications, they
will be ineligible to participate in this study

- Patients with malabsorption syndrome or other condition that would interfere with
intestinal absorption

- Diarrhea > grade 1 despite appropriate therapy

- Patients who are serologically positive for hepatitis A, B or C are ineligible

- Patients with > grade 1 (by CTCAE criteria) hyponatremia or hypocalcemia (based on
measurement of ionized calcium), despite appropriate medical management are excluded
from this study, as are patients with hypophosphatemia (serum phosphate below the
lower limit of normal for the institution), hypomagnesemia, (serum magnesium below
the lower limit of normal), hypokalemia, or hyperkalemia (serum potassium outside
normal limits) despite appropriate medical management

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection requiring systemic therapy (with antibiotics, antiviral or antifungal
agents), symptomatic congestive heart failure, unstable angina pectoris, angina at
rest, a history of torsades des pointes, potentially life-threatening cardiac
arrhythmias (patients are permitted to have chronic, stable atrial fibrillation,
premature atrial or ventricular contractions, sinus tachycardia, provided the rate is
controlled at < 115 per minute, and sinus bradycardia, provided the rate is > 50 per
minute), myocardial infarction within the previous 3 months, or psychiatric
illness/social situations that would limit compliance with study requirements

- Pregnant women are excluded from this study because RO4929097 is a Notch pathway
inhibiting agent with the potential for teratogenic or abortifacient effects

- HIV-positive patients on combination antiretroviral therapy are ineligible because of
the potential for pharmacokinetic interactions with RO4929097

- Cardiovascular: baseline QTcF > 450 msec (male) or QTcF > 470 msec (female)

- Patients requiring drugs that are known to cause torsades des pointes and/or
prolonged QTc intervals are excluded; patients requiring drugs with a possible but
unproven association with torsades des pointes and/or QTc prolongation may be
eligible, but will require additional electrocardiogram assessments

- Patients who have not recovered to < CTCAE grade 2 toxicities related to prior
therapy are not eligible to participate in this study