Inclusion Criteria

Inclusion criteria:

- Histologically or cytologically proven solid malignant tumor at the first diagnosis
with the exception of squamous non small cell lung cancer (NSCLC).

- Advanced neoplastic disease (i.e. metastatic or locally unresectable advanced
disease)

- Presence of one measurable lesion at baseline in the MTD expanded cohort

Exclusion criteria:

- ECOG (Eastern cooperativeOncology Group) performance status > 1

- Concurrent treatment with any other anticancer therapy

- Pericardial effusion requiring intervention (drainage)

- History of brain metastasis, spinal cord compression or carcinomatous meningitis or
new evidence of brain metastasis on screening Computed tomography (CT) or Magnetic
resonance imaging (MRI) scan

- Diagnosis of squamous Non Squamous Cell Lung Cancer (NSCLC) or with mixed cell type
with predominant squamocellular histology

- Hormone sensitive prostate cancer

- Abdominal Radiotherapy

- Major surgery within the last month of study enrollment or surgical wound not fully
healed before study enrollment

- High cumulative doses of anthracycline

- Inadequate organ function

- Inadequate hematology function or poor bone marrow reserve

- Any of the following within 6 months prior to study enrollment: peptic ulcer disease,
erosive oesophagitis or gastritis, infectious or inflammatory bowel disease and
diverticulitis

- Any history or underlying cardiac condition that may increase the risks associated
with the study participation or administration of the investigational products, or
that may interfere with the interpretation of the results.

The above information is not intended to contain all considerations relevant to a
patient's potential participation in a clinical trial.