Trial Information
Retrospective Analysis of ERCC1 Expression in Patients With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) Who Received Cisplatin or Cisplatin and Cetuximab
OBJECTIVES:
- To investigate the association between ERCC1 expression and clinical outcomes (response
rate, progression-free survival, and overall survival) in patients with recurrent
and/or metastatic squamous cell carcinoma of the head and neck who received cisplatin
with versus without cetuximab on clinical trial ECOG-E5397.
OUTLINE: Archived tumor tissue samples are analyzed for ERCC1 expression by IHC. ERCC1
levels (low or high) are assessed by an H-score and AQUA, a quantitative IHC analysis. Each
patient's ERCC1 level result is then compared with the patient's clinical outcome.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of squamous cell carcinoma of the head and neck
- Recurrent and/or metastatic disease
- Received cisplatin with or without cetuximab on clinical trial ECOG-E5397
- Slides and blocks of tumor specimens available
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Association between ERCC1 expression (low or high) with clinical outcomes
Safety Issue:
No
Principal Investigator
Ranee Mehra, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Fox Chase Cancer Center
Authority:
Unspecified
Study ID:
CDR0000683281
NCT ID:
NCT01192750
Start Date:
September 2010
Completion Date:
Related Keywords:
- Head and Neck Cancer
- recurrent metastatic squamous neck cancer with occult primary
- recurrent squamous cell carcinoma of the hypopharynx
- recurrent squamous cell carcinoma of the larynx
- recurrent squamous cell carcinoma of the lip and oral cavity
- recurrent squamous cell carcinoma of the nasopharynx
- recurrent squamous cell carcinoma of the oropharynx
- recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IV squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the larynx
- stage IV squamous cell carcinoma of the lip and oral cavity
- stage IV squamous cell carcinoma of the nasopharynx
- stage IV squamous cell carcinoma of the oropharynx
- stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
- recurrent verrucous carcinoma of the larynx
- recurrent verrucous carcinoma of the oral cavity
- stage IV verrucous carcinoma of the larynx
- stage IV verrucous carcinoma of the oral cavity
- recurrent salivary gland cancer
- salivary gland squamous cell carcinoma
- Carcinoma, Squamous Cell
- Neoplasms, Squamous Cell
- Head and Neck Neoplasms