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Retrospective Analysis of ERCC1 Expression in Patients With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) Who Received Cisplatin or Cisplatin and Cetuximab


N/A
18 Years
N/A
Not Enrolling
Both
Head and Neck Cancer

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Trial Information

Retrospective Analysis of ERCC1 Expression in Patients With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) Who Received Cisplatin or Cisplatin and Cetuximab


OBJECTIVES:

- To investigate the association between ERCC1 expression and clinical outcomes (response
rate, progression-free survival, and overall survival) in patients with recurrent
and/or metastatic squamous cell carcinoma of the head and neck who received cisplatin
with versus without cetuximab on clinical trial ECOG-E5397.

OUTLINE: Archived tumor tissue samples are analyzed for ERCC1 expression by IHC. ERCC1
levels (low or high) are assessed by an H-score and AQUA, a quantitative IHC analysis. Each
patient's ERCC1 level result is then compared with the patient's clinical outcome.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of squamous cell carcinoma of the head and neck

- Recurrent and/or metastatic disease

- Received cisplatin with or without cetuximab on clinical trial ECOG-E5397

- Slides and blocks of tumor specimens available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Association between ERCC1 expression (low or high) with clinical outcomes

Safety Issue:

No

Principal Investigator

Ranee Mehra, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fox Chase Cancer Center

Authority:

Unspecified

Study ID:

CDR0000683281

NCT ID:

NCT01192750

Start Date:

September 2010

Completion Date:

Related Keywords:

  • Head and Neck Cancer
  • recurrent metastatic squamous neck cancer with occult primary
  • recurrent squamous cell carcinoma of the hypopharynx
  • recurrent squamous cell carcinoma of the larynx
  • recurrent squamous cell carcinoma of the lip and oral cavity
  • recurrent squamous cell carcinoma of the nasopharynx
  • recurrent squamous cell carcinoma of the oropharynx
  • recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage IV squamous cell carcinoma of the hypopharynx
  • stage IV squamous cell carcinoma of the larynx
  • stage IV squamous cell carcinoma of the lip and oral cavity
  • stage IV squamous cell carcinoma of the nasopharynx
  • stage IV squamous cell carcinoma of the oropharynx
  • stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
  • recurrent verrucous carcinoma of the larynx
  • recurrent verrucous carcinoma of the oral cavity
  • stage IV verrucous carcinoma of the larynx
  • stage IV verrucous carcinoma of the oral cavity
  • recurrent salivary gland cancer
  • salivary gland squamous cell carcinoma
  • Carcinoma, Squamous Cell
  • Neoplasms, Squamous Cell
  • Head and Neck Neoplasms

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