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Association of Smoking, Lung Inflammation and Lung Metastases From Breast Cancer

18 Years
Open (Enrolling)
Breast Cancer

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Trial Information

Association of Smoking, Lung Inflammation and Lung Metastases From Breast Cancer

Inclusion Criteria:

- Registered patient at MSKCC

- Histologically proven breast cancer. It is not necessary that pathology be reviewed

- Age ≥18 years Group 1 (A and B)

- Diagnosed with metastatic breast cancer on biopsy or imaging study.

- Patients will be considered to have lung metastases, and will be assigned to group 1A
if any of the following criteria are met, otherwise patients will be assigned to
group 1B "No known Lung Metastases," Biopsy-proven lung metastasis.

- Pleural effusion with cytologic evidence of malignancy.

- Pleural effusion, exudative in character, without alternative explanation and
attributed, in the opinion of the clinician to metastatic disease.

- Symptoms attributable to lung metastases and a radiological pattern interpreted by a
radiologist as suspicious for metastatic disease.

- Any pulmonary nodule on chest radiograph, CT scan, PET-CT or MRI, which is
interpreted by the clinician and radiologist to be metastatic in etiology, whether or
not a biopsy was performed, and regardless of symptoms.

- A radiographic pattern interpreted by a radiologist as consistent with lymphangitic

Group 2 (Controls)

- History of early breast cancer and currently no evidence of disease

Exclusion Criteria:

- Inability to provide written informed consent.

- Inability to complete smoking and NSAID questionnaire.

- Steroid use within the previous 4 weeks.

- Radiotherapy to the breast, chest wall or axilla within the previous 3 months.

- Men with breast cancer.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

The association between urinary PGE-M and the presence or absence of lung metastases

Outcome Description:

in patients with breast cancer

Outcome Time Frame:

2 years

Safety Issue:


Principal Investigator

Clifford Hudis, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

August 2010

Completion Date:

August 2013

Related Keywords:

  • Breast Cancer
  • lung inflammation
  • lung metastases
  • 10-115
  • Breast Neoplasms
  • Inflammation
  • Neoplasm Metastasis
  • Pneumonia
  • Lung Neoplasms



Memorial Sloan Kettering Cancer CenterNew York, New York  10021