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Neurobehavioral Functioning and Utilization of Special Education Services in Pediatric Brain and CNS Tumor Patients After Proton Radiation Treatment: A Longitudinal Study


N/A
2 Years
25 Years
Open (Enrolling)
Both
Brain Tumor, Central Nervous System Neoplasms

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Trial Information

Neurobehavioral Functioning and Utilization of Special Education Services in Pediatric Brain and CNS Tumor Patients After Proton Radiation Treatment: A Longitudinal Study


The purpose of this study is to longitudinally examine neurobehavioral functioning outcomes
and use of special education services in brain tumor and CNS tumor patients treated with
proton radiation at MGH. Furthermore, we seek to correlate neurobehavioral data with
pertinent clinical information. We anticipate better neurobehavioral functioning to be
associated with use of protons (vs. photons, as reported in the literature). We also
anticipate the need and utilization of special education services to be lower in brain and
CNS tumor patients treated with protons (vs. photons, as reported in the literature).
Lastly, we anticipate greater neurobehavioral deficits in patients whose proton radiation
treatment involved the craniospinal axis compared to those who received proton radiation to
the involved field.


Inclusion Criteria:



1. Children diagnosed with brain or CNS tumors and treated with proton radiation therapy
at the MGH Francis H. Burr Proton Center since September 2002

2. Patients received baseline neurocognitive testing at MGH

3. Patients ≤25 years at the time of diagnosis

4. Tumor location in the brain or CNS

5. Radiation treatment consisted of only proton radiotherapy

6. No prior radiation exposure or chemotherapy

Exclusion Criteria:

1. Patients receiving treatment with palliative intent

2. Patients who do not wish to participate

3. Patient is deceased at ≥1 year follow-up

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Behavior Rating Inventory of Executive Functioning

Outcome Description:

Questionnaire of executive functioning in children and young adults

Outcome Time Frame:

Approximately one year post proton radiation treatment

Safety Issue:

No

Principal Investigator

Margaret B. Pulsifer, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Massachusetts General Hospital

Authority:

United States: Institutional Review Board

Study ID:

2009A058394

NCT ID:

NCT01180881

Start Date:

October 2009

Completion Date:

March 2013

Related Keywords:

  • Brain Tumor
  • Central Nervous System Neoplasms
  • Proton Radiation
  • CNS tumors
  • Brain Tumors
  • Neurobehavioral functioning
  • Brain Neoplasms
  • Neoplasms
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms

Name

Location

Massachusetts General HospitalBoston, Massachusetts  02114-2617