Cognitive Benefits of Aerobic Exercise Across the Age Span
While animal and human studies indicate cognitive benefits from aerobic exercise across the
lifespan, the great majority of controlled exercise studies in humans have been restricted
to elderly individuals. Those studies have indicated that enhancing aerobic capacity has a
beneficial effect on cognition. One study suggests that this benefit is seen particularly
for executive control processes, precisely the processes affected by aging. These
improvements have been accompanied by increases in gray matter density and changes in
functional magnetic resonance imaging (fMRI) patterns of task-related activation. The goal
of the proposed study is to extend the investigation of the beneficial effects of aerobic
exercise to younger individuals, and to compare these effects in young and old.
In this application we propose to conduct a study in which 260 sedentary but otherwise
healthy and cognitively intact individuals in 2 age groups, young (25-40) and younger old
(50-65), are randomized to two training conditions, aerobic exercise and stretching/toning,
to be completed at The Plus One Fitness Center at Columbia University. Subjects will be
assessed for aerobic capacity, cognitive task performance, and by structural MRI, resting
cerebral blood flow scans (arterial spin labeling) and cognitive activation fMRI studies at
study entry and after 6 months of training.
We also propose two complementary approaches to investigating the neural correlates of the
beneficial effects of aerobic exercise on cognition: 1) imaging -- we will use a
combination of structural, metabolic, and cognitive activation fMRI studies to evaluate the
neural substrates of the effect of aerobic exercise on cognition. 2) important correlates
-- we will explore the effects of apolipoprotein E (APOE) genotype, inflammatory markers and
cognitive reserve on the cognitive effects of aerobic exercise.
Interventional
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
Change from baseline in measures of executive control function and episodic memory at 6 months
tests of global intelligence, executive function, working memory and processing speed
24 weeks
No
Richard P Sloan, PhD
Principal Investigator
Columbia University
United States: Institutional Review Board
6211
NCT01179958
August 2010
August 2015
Name | Location |
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Columbia University Medical Center | New York, New York 10032 |