Evaluating Patient Preferences for the Treatment of Localized Prostate Cancer - A Discrete Choice Experiment
- To evaluate the importance of prostate cancer treatment characteristics to men with
localized prostate cancer.
- To determine to what extent men will choose the strengths and weaknesses of one
treatment over a different set of strengths and weaknesses of another treatment when
making a choice between them.
- To determine the correlation between attributes that are important to men and baseline
demographics, functional status, and disease risk characteristics.
OUTLINE: This is a multicenter study.
Patients complete a 'discrete choice experiment' questionnaire presenting three treatment
options based on 8 aspects of treatment. Attributes relevant to men with prostate cancer
(e.g., sexual health, urinary function, return to normal activities [work, gardening,
sports, shopping]) that apply to surveillance, radical therapies and new minimally-invasive
therapies have been selected for consideration. Baseline demographics such as age,
working/retired/unemployed/household income, prostate cancer characteristics (PSA level,
Gleason grade, stage), baseline functional status (genitourinary function), and final
treatment choice will also be collected in order to ascertain whether there is any
relationship and association between patient preferences for treatment and these baseline
demographics. Individuals will be asked to choose between the three treatment profiles.
Primary Purpose: Health Services Research
Preferences for, and trade-offs between, the attributes of pre-treatment evaluation with general anaesthetic biopsies and post-treatment frequency of biopsies
Mark Emberton, MD, FRCS, MBBS
University College London Hospitals