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Collection of Blood and/or Bone Marrow for Investigation and Characterization of Normal and Abnormal Cell Growth in Patients With Malignancy or Hematologic Disorders


N/A
18 Years
N/A
Open (Enrolling)
Both
Leukemia

Thank you

Trial Information

Collection of Blood and/or Bone Marrow for Investigation and Characterization of Normal and Abnormal Cell Growth in Patients With Malignancy or Hematologic Disorders


Inclusion Criteria:



- Selected patients over the age of 18 with hematologic malignancies or other blood
disorders (leukemia, myeloproliferative disorders, lymphoma, other malignancies
involving the bone marrow or patients with unexplained alterations in their complete
blood count).

Patients who are scheduled to undergo a bone marrow aspirate and/or phlebotomy for other
clinical indications will be asked to participate. They will be asked to donate an
additional small aliquot of bone marrow and/or blood during the course of their already
scheduled bone marrow aspiration or phlebotomy.

Exclusion Criteria:

- Patients with pre-existing medical conditions that might be exacerbated by the
procedure of obtaining bone marrow or blood

- Patients who are allergic to Lidocaine, which is used as a local anesthetic, and who
cannot receive a suitable substitute anesthetic.

- Patients who have a bleeding diathesis which might pose a problem with marrow
aspiration.

- Patients unable to give informed consent.

- Pregnant patients

Type of Study:

Observational

Study Design:

Time Perspective: Prospective

Outcome Measure:

The study is designed to collect blood and bone marrow from patients with various hematological diseases.

Outcome Description:

The study is designed to collect blood and bone marrow from patients with various hematological diseases. The samples will be used for various research studies for better understanding of biology of various blood disorders including hematological malignancies. Relevant clinical and laboratory features and subsequent changes will be noted for correlation with these studies. The tissue/cells will be additionally banked and/or used for other investigations in the future.

Outcome Time Frame:

On average, indefinite, or until death of participant

Safety Issue:

No

Principal Investigator

Jan Cerny, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Massachusetts, Worcester

Authority:

United States: Institutional Review Board

Study ID:

UM200901

NCT ID:

NCT01174615

Start Date:

September 2009

Completion Date:

December 2100

Related Keywords:

  • Leukemia
  • Blood/bone marrow collection, hematologic diseases, leukemia
  • Leukemia

Name

Location

University of Massachusetts Medical SchoolWorcester, Massachusetts  01605