Inclusion Criteria:

- Evidence of progressive disease in the above categories evaluated by standard tumor
staging.

- Histologically confirmed diagnosis.

- Failure of conventional anti- cancer modalities.despite optimal application of all
relevant available anti- cancer modalities.

- Age between 3 and 75 years old.

- Liver function tests less than twice the normal, renal function no more than 20%
reduction and white cell and platelets count no more than 30% reduction.

- Karnofsky performance status of 50% or greater

- A written informed consent understood and signed by the patient and by a spouse,
parent or guardian. In patients with GBM two signs will be required due to possible
alterations of psych and understanding.

Exclusion Criteria:

- Not fulfilling any of the above criteria

- Moribund patients or patients with life- expectancy < 3 months

- Karnofksy performance status < 50%

- Pregnant or lactating women

- Active local or systemic infections requiring treatment

- Patients receiving other investigational agents

- History of allergy to egg ova-albumin.

- Co-morbidity or life- threatening clinical condition other than the basic cancer