Effect of Intermittent Hepatic Inflow Occlusion During Donor Hepatectomy In Adult Living Donor Liver Transplantation Using Right Hemiliver Grafts
Intermittent hepatic inflow occlusion (IHIO) by clamping of the portal triad, also called
Pringle maneuver, is a safe and effective procedure in major hepatectomy in patients with
liver disease. IHIO minimizes blood loss and operation time during liver resection. In
addition, ischemic preconditioning with IHIO has been reported to have protective effects in
patients undergoing liver resection. In the setting of living donor liver transplantation
(LDLT), one of the most important concerns is liver donor safety. Several studies have shown
the safety of IHIO in donors for liver transplantation (LT). However, the effect of
preconditioning with IHIO during donor hepatectomy on LDLT recipients remains unclear.
Several small series have assessed the effects on recipients of ischemic preconditioning
during whole liver transplantation from deceased donors. The role of IHIO, however, has not
been fully elucidated in liver donors and recipients during LDLT. In this randomized,
prospective study, we'll evaluate the efficacy of IHIO in the recipients and donors.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Serum alanine aminotransferase (ALT) concentration within 5 days post-operative
The primary end-point of this study is peak serum alanine aminotransferase (ALT) concentration within 5 days post-operation on donors and recipients.
pre-operative and every day till 5 days post-operative
Jae-Won Joh, MD., PhD
Samsung Medical Center
South Korea: Institutional Review Board