Circadian Disturbances After Breast Cancer Surgery
An increasing number of studies have shown that circadian variation in the excretion of
hormones, the sleep-wake cycle, the core body temperature, the tone of the autonomic nervous
system and the activity rhythm are important both in health and disease processes. More
attention is being paid towards the circadian variation in endogenous rhythms in relation to
surgery and whether this can affect postoperative recovery, morbidity and mortality.
Studies have been done on circadian disturbances after major and minor surgery but never in
relation to breast cancer surgery.
This study will investigate circadian disturbances in this specific group of patients by
using Actigraphy, Polysomnography (PSG), Holter-monitoring (HRV), the primary metabolite of
melatonin in urine 6-sulfatoxymelatonin (aMT6s), questionnaires and a sleep-diary.
Observational Model: Cohort, Time Perspective: Prospective
Preoperative sleep architecture of breast cancer patients
Sleep architecture measured by Polysomnography (awake, stadium I-IV, REM sleep, sleep latency, awakenings).
1 day preoperatively
Melissa V Hansen, MD
Denmark: The Danish National Comittee on Biomedical Research Ethics