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Circadian Disturbances After Breast Cancer Surgery

30 Years
70 Years
Not Enrolling
Circadian Rhythm Disorders, Anxiety, Breast Cancer

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Trial Information

Circadian Disturbances After Breast Cancer Surgery

An increasing number of studies have shown that circadian variation in the excretion of
hormones, the sleep-wake cycle, the core body temperature, the tone of the autonomic nervous
system and the activity rhythm are important both in health and disease processes. More
attention is being paid towards the circadian variation in endogenous rhythms in relation to
surgery and whether this can affect postoperative recovery, morbidity and mortality.

Studies have been done on circadian disturbances after major and minor surgery but never in
relation to breast cancer surgery.

This study will investigate circadian disturbances in this specific group of patients by
using Actigraphy, Polysomnography (PSG), Holter-monitoring (HRV), the primary metabolite of
melatonin in urine 6-sulfatoxymelatonin (aMT6s), questionnaires and a sleep-diary.

Inclusion Criteria:

- women, age 30-70, with breast cancer who are admitted for a lumpectomy at Herlev

- ASA score I-III

Exclusion Criteria:

- Known sleep apnea

- Pre-operative treatment with beta-blockers

- Diabetes Mellitus

- Known pre-operative depressive illness or dementia

- Previous or current cancer

- Known medically treated sleep-disorder (insomnia, restless legs etc)

- Shift-work

- Daily alcohol intake of more than 5 units

- Pre-operative treatment with psychopharmacological drugs, opioids or anxiolytics
(including all sleeping pills)

- Predicted bad compliance

- Pregnant or breast-feeding

- Pre- or post-operative complications or events which are expected to increase
morbidity or pain the first post-operative days.

- Missing written consent

- Pre-operative MMSE score less than 24

- Urine or fecal incontinence

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Preoperative sleep architecture of breast cancer patients

Outcome Description:

Sleep architecture measured by Polysomnography (awake, stadium I-IV, REM sleep, sleep latency, awakenings).

Outcome Time Frame:

1 day preoperatively

Safety Issue:


Principal Investigator

Melissa V Hansen, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Herlev Hospital


Denmark: The Danish National Comittee on Biomedical Research Ethics

Study ID:




Start Date:

February 2011

Completion Date:

November 2011

Related Keywords:

  • Circadian Rhythm Disorders
  • Anxiety
  • Breast Cancer
  • Circadian Rhythm Disorders
  • Breast Neoplasms Surgery
  • Sleep
  • Heart Rate
  • Anxiety Disorders
  • Breast Neoplasms
  • Chronobiology Disorders